Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021

IF 1.6 Q4 INFECTIOUS DISEASES

Journal of clinical virology plus Pub Date : 2022-11-01 DOI:10.1016/j.jcvp.2022.100110

Silvia Baroncelli , Clementina Maria Galluzzo , Stefano Orlando , Robert Mphwere , Thom Kavalo , Richard Luhanga , Roberta Amici , Marco Floridia , Mauro Andreotti , Paola Scarcella , Maria Cristina Marazzi , Marina Giuliano

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引用次数: 1

Abstract

Background

Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries.

Objective

In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants.

Study design

Blood samples (n = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain.

Results

The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, P = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices.

Conclusions

Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa.

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2020年2月至2021年5月期间马拉维婴儿接触SARS-CoV-2的动态

关于撒哈拉以南国家婴儿中SARS-CoV-2血清流行率的信息非常有限。目的研究马拉维母乳喂养婴儿SARS - CoV-2血清阳性率及其时间演变。研究设计从2020年2月至2021年5月收集的158名婴儿(艾滋病毒阴性妇女和艾滋病毒感染妇女所生)的血液样本(n = 250)，首先使用针对三聚体刺突蛋白的抗IgG/A/M SARS CoV 2酶联免疫吸附试验进行检测，如果阳性，则使用第二次酶联免疫吸附试验检测针对受体结合域的IgG进行确认。结果新生儿抗sars CoV-2抗体阳性率为31.0% (95% CI: 23.7% ~ 38.3%)， hiv暴露组与未暴露组间差异无统计学意义(分别为29.3%和37.1%，P = 0.410)。抗sars - cov -2 IgG的存在与产妇的社会经济或人口统计学指标无关。结论sour数据强调了SARS-CoV-2感染在撒哈拉以南非洲儿童人群中的广泛传播。为更严格地监测非洲SARS-CoV-2感染动态，需要为非洲样本设计更具体的血清学检测并改进血清监测规划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of clinical virology plus Infectious Diseases

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

66 days