Mesenchymal stem cell-derived extracellular vesicles: a possible therapeutic strategy for orthopaedic diseases: a narrative review.

Biomaterials Translational Pub Date : 2022-01-01 DOI:10.12336/biomatertransl.2022.03.002

Zhao-Lin Zeng, Hui Xie

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引用次数: 7

Abstract

Accumulating evidence suggests that the therapeutic role of mesenchymal stem cells (MSCs) in bone diseases is closely related to paracrine-generated extracellular vesicles (EVs). MSC-derived EVs (MSC-EVs) carry proteins, nucleic acids, and lipids to the extracellular space and affect the bone microenvironment. They have similar biological functions to MSCs, such as the ability to repair organ and tissue damage. In addition, MSC-EVs also have the advantages of long half-life, low immunogenicity, attractive stability, ability to pass through the blood-brain barrier, and demonstrate excellent performance with potential practical applications in bone diseases. In this review, we summarise the current applications and mechanisms of MSC-EVs in osteoporosis, osteoarthritis, bone tumours, osteonecrosis of the femoral head, and fractures, as well as the development of MSC-EVs combined with materials science in the field of orthopaedics. Additionally, we explore the critical challenges involved in the clinical application of MSC-EVs in orthopaedic diseases.

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间充质干细胞衍生的细胞外囊泡:一种可能的骨科疾病治疗策略:叙述性回顾。

越来越多的证据表明，间充质干细胞(MSCs)在骨病中的治疗作用与旁分泌生成的细胞外囊泡(EVs)密切相关。msc - ev (msc - ev)携带蛋白质、核酸和脂质到细胞外空间并影响骨微环境。它们具有与间充质干细胞相似的生物学功能，比如修复器官和组织损伤的能力。此外，msc - ev还具有半衰期长、免疫原性低、稳定性好、能穿过血脑屏障等优点，在骨病治疗中表现出优异的性能，具有潜在的实际应用前景。本文综述了msc - ev在骨质疏松症、骨关节炎、骨肿瘤、股骨头坏死、骨折等方面的应用及机制，以及msc - ev与材料科学在骨科领域的结合研究进展。此外，我们还探讨了msc - ev在骨科疾病中的临床应用所面临的关键挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Translational

CiteScore

6.70

自引率

0.00%

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