In vivo degradation and bone reaction of long-term fixation with a magnesium alloy made by twin-roll casting in a rat femur model.

IF 1 4区医学 Q4 ENGINEERING, BIOMEDICAL

Bio-medical materials and engineering Pub Date : 2023-01-01 DOI:10.3233/BME-221415

Ying Zhang, Haijian Wang, Takashi Kumazawa, Dongying Ju

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引用次数: 0

Abstract

Background: The effect of casting parameters on the microstructure and corrosion resistance of Mg alloys is still limited, especially in clinical animal experiments.

Objective: We prepared a new magnesium rare earth alloy (Mg-Re, where Re is Ce or La) by vertical two-roll casting and Mg-A by further rolling. The microstructure characteristics, degradation behavior, and bone reaction of the two alloys were studied.

Method: Ti, Mg-Re, and Mg-A alloy plates were implanted in a rat femur model, and their degradation behavior was observed 48 weeks later.

Results: In vivo experiments showed no significant changes around the femur in the Ti group, excluding external factors that may cause bone remodeling and lead to new bone formation. Mg-A induces more new bone formation than Mg-Re, which meets the necessary conditions to prevent pathological fracture. The specimen staining and sectioning showed that the liver and heart of rats implanted with magnesium alloys had no pathological changes and the cell structure was normal, similar to that of rats without a magnesium alloy.

Conclusion: Mg-A alloy has good healing potential as a biodegradable implant material.

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大鼠股骨模型中双辊铸造镁合金长期固定的体内降解和骨反应。

背景:铸造参数对镁合金显微组织和耐蚀性的影响仍然有限，特别是在临床动物实验中。目的:采用垂直双辊铸造法制备新型镁稀土合金(Mg-Re，其中Re为Ce或La)，进一步轧制制备Mg-A。研究了两种合金的显微组织特征、降解行为和骨反应。方法:将Ti、Mg-Re、Mg-A合金板植入大鼠股骨模型，观察其48周后的降解行为。结果:体内实验显示，Ti组股骨周围无明显变化，排除了可能导致骨重塑和新骨形成的外部因素。Mg-A比Mg-Re诱导更多的新骨形成，满足预防病理性骨折的必要条件。标本染色和切片显示，植入镁合金的大鼠肝脏和心脏无病理改变，细胞结构正常，与未植入镁合金的大鼠相似。结论:Mg-A合金是一种具有良好愈合潜力的生物降解种植材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bio-medical materials and engineering 工程技术-材料科学：生物材料

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.