Effects of Aqueous Extract of Terminalia catappa L. on Membrane Stability of Sickle Cell Erythrocytes

International Blood Research & Reviews Pub Date : 2020-12-14 DOI:10.9734/ibrr/2020/v11i430136

E. Chukwunyere, PAUL CHIDOKA CHIKEZIE, P. C. Anuforo, J. Adejor, H. Nwankwo

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引用次数: 1

Abstract

Background: The effects of 800 mg% aqueous extract of T. catappa on membrane stability of human erythrocytes of HbSS genotype were investigated using in vitro studies. Aim: The aim of the study was to determine the membrane stabilizing potential of aqueous extract of T. catappa on sickle cell erythrocytes. Study Design: Laboratory Experimental Design was used in this study. Place and Duration: Department of Biochemistry, Imo State University, Owerri, Nigeria. The study was carried out between November, 2010 and May, 2011. Materials and Methods: Spectrophotometric method was employed in determining the osmotic fragility index of HbSS erythrocytes. The mean corpuscular fragility (MCF) of the control was 0.422 ± 0.80 g/100 ml, whereas that of the test sample was 0.36 ± 0.014 g/100 ml. The percentage stabilization for the HbSS erythrocytes, which was calculated using the MCF values, was 14.28%. The MCF values of the control and the test showed significant difference (p < 0.05). Results: The result showed that aqueous extract of T. catappa exhibited an increasing capacity to stabilize HbSS erythrocytes membrane. Conclusion: The present study showed that aqueous extract of T. catappa L. exhibited membrane stability potential on sickle cell erythrocytes.

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刺尾草水提物对镰状红细胞膜稳定性的影响

背景:采用体外实验方法，研究了800 mg%水提物对人HbSS基因型红细胞膜稳定性的影响。目的:研究石刺草水提物对镰状红细胞的膜稳定电位。研究设计:本研究采用实验室实验设计。地点和时间:尼日利亚奥韦里伊莫州立大学生物化学系。该研究于2010年11月至2011年5月进行。材料与方法:采用分光光度法测定HbSS红细胞的渗透脆性指数。对照组的平均红细胞易碎性(MCF)为0.422±0.80 g/100 ml，而试验组的平均MCF为0.36±0.014 g/100 ml。根据MCF值计算，HbSS红细胞的稳定百分比为14.28%。对照组与试验组MCF值差异有统计学意义(p < 0.05)。结果:水提物对HbSS红细胞膜的稳定作用增强。结论:水提物对镰状红细胞具有膜稳定潜能。

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International Blood Research & Reviews

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