Future application of deubiquitylating enzymes for rapid and efficient cellular reprogramming

Abstract

Abbreviations: DUB, deubiquitylating enzyme; ESCs, embryonic stem cells; ICM, inner cell mass; PTM, post-translational modification; iPSCs, induced pluripotent stem cells; USP, ubiquitin-specific processing protease; UCH, ubiquitin carboxy-terminal hydrolase; OUT, otu-domain ubiquitin aldehyde binding protein; JAMM, jad1/pad/mpn-domain-containing metalloenzyme; MCPIP, monocyte chemotactic protein-induced protease; PSC, pluripotent stem cell; CNS, central nervous system; CPP, cell penetrating peptide; piPSCs, protein-induced pluripotentstem cells; WWP2, ww domain-containing protein 2; UPS, ubiquitin proteasome system; MEFs, mouse embryonic fibroblasts; FBXW8, f-box/wd repeat-containing protein 8