Efficacy of Neutrophil-to-Lymphocyte Ratio for Cancer-Specific Survival in Elderly Patients with Localized Colon Cancer: A Single Center Propensity Score-Matched Analysis.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Experimental Gastroenterology Pub Date : 2023-01-01 DOI:10.2147/CEG.S385207

Tetsuro Tominaga, Takashi Nonaka, Shosaburo Oyama, Yuma Takamura, Shintaro Hashimoto, Toshio Shiraishi, Terumitsu Sawai, Takeshi Nagayasu

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引用次数: 1

Abstract

Purpose: The prognostic value of neutrophil-to-lymphocyte ratio (NLR) has been studied for colorectal cancer. Elderly patients in general tend to have comorbidities and decreased organ function that potentially influence the NLR score. The aim of this study was to investigate the relationship between NLR and cancer-specific survival in elderly patients with colon cancer, using a propensity score-matched analysis.

Patients and methods: A total of 203 patients aged over 75 years who underwent curative resection for colon cancer and were diagnosed pathologically with stage II/III disease were eligible for entry to the study. Patients were divided into two groups according to NLR score: NLR-High (NLR≥4.5) group (NLR-H, n=60) and NLR-Low (NLR<4.5) group (NLR-L, n=143). After propensity score matching, 57 patients in each group were matched.

Results: Before matching, Charlson comorbidity index was significantly higher in the NLR-H group (4 vs 2, p<0.001). After matching, all factors were similar between the groups. The median follow-up period was 43 months (range, 1-160 months). Five-year relapse-free-survival (69.8% vs 87.3%, p=0.030) and cancer-specific survival (83.0% vs 96.0%, p=0.042) were significantly lower in the NLR-H group.

Conclusion: NLR appears to be a cancer-specific prognostic marker in elderly patients with colon cancer.

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中性粒细胞与淋巴细胞比值对老年局限性结肠癌患者癌症特异性生存率的影响:单中心倾向评分匹配分析

目的:探讨中性粒细胞与淋巴细胞比值(NLR)对大肠癌的预后价值。老年患者通常有合并症和器官功能下降，这可能会影响NLR评分。本研究的目的是通过倾向评分匹配分析，探讨老年结肠癌患者NLR与癌症特异性生存率之间的关系。患者和方法:203例75岁以上接受根治性结肠癌切除术且病理诊断为II/III期的患者符合入组研究条件。根据NLR评分将患者分为两组:NLR-高(NLR≥4.5)组(NLR- h, n=60)和NLR-低(NLR)组(NLR- h组，n=60)。结果:配对前，NLR- h组Charlson合病指数明显高于NLR- h组(4比2,p)。

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