Ala’ Assaf, Mario Mekhael, Charbel Noujaim, Nour Chouman, Hadi Younes, Omar Kreidieh, Nassir Marrouche, Eoin Donnellan
{"title":"Conduction system disease in cardiac amyloidosis","authors":"Ala’ Assaf, Mario Mekhael, Charbel Noujaim, Nour Chouman, Hadi Younes, Omar Kreidieh, Nassir Marrouche, Eoin Donnellan","doi":"10.1016/j.tcm.2023.02.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Cardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with more mortality, morbidity, and hospitalizations. While AF increases the risk of thrombosis regardless of the CHA</span><sub>2</sub>DS<sub>2</sub><span><span>-VASc score, the risk of thromboembolism<span> seems to be high even in CA patients without AF. AV Nodal disease is prevalent and may precede the diagnosis of CA. The incidence of ventricular arrhythmias remains disputed, and the role of </span></span>implantable cardioverter defibrillator<span> devices in CA patients is controversial. Newer therapies targeted against specific types of CA have been developed, but their effects on conductive system disease are not well studied.</span></span></p></div>","PeriodicalId":51199,"journal":{"name":"Trends in Cardiovascular Medicine","volume":"34 4","pages":"Pages 250-253"},"PeriodicalIF":7.3000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Cardiovascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S105017382300021X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Cardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with more mortality, morbidity, and hospitalizations. While AF increases the risk of thrombosis regardless of the CHA2DS2-VASc score, the risk of thromboembolism seems to be high even in CA patients without AF. AV Nodal disease is prevalent and may precede the diagnosis of CA. The incidence of ventricular arrhythmias remains disputed, and the role of implantable cardioverter defibrillator devices in CA patients is controversial. Newer therapies targeted against specific types of CA have been developed, but their effects on conductive system disease are not well studied.
心脏淀粉样变性（CA）对传导系统有多种有害影响。心房颤动是迄今为止最常见的心脏淀粉样变性电生理表现，与更高的死亡率、发病率和住院率相关。虽然无论 CHA2DS2-VASc 评分如何，心房颤动都会增加血栓形成的风险，但即使没有心房颤动的 CA 患者，血栓栓塞的风险似乎也很高。房室结疾病很普遍，可能在确诊 CA 之前就已存在。室性心律失常的发生率仍有争议，植入式心脏除颤器在 CA 患者中的作用也存在争议。针对特定类型 CA 的新疗法已经开发出来，但其对传导系统疾病的影响尚未得到充分研究。
期刊介绍：
Trends in Cardiovascular Medicine delivers comprehensive, state-of-the-art reviews of scientific advancements in cardiovascular medicine, penned and scrutinized by internationally renowned experts. The articles provide authoritative insights into various topics, encompassing basic mechanisms, diagnosis, treatment, and prognosis of heart and blood vessel disorders, catering to clinicians and basic scientists alike. The journal covers a wide spectrum of cardiology, offering profound insights into aspects ranging from arrhythmias to vasculopathies.
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