Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from Croton argyrophylloides.

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Rafael Carneiro Bastos, Carlos Franciney Moreira Vasconcelos, Marcela Bezerra Paiva, Thomas Dominik de Sousa Dos Reis, Ricardo Basto Souza, Hélcio Silva Dos Santos, Paulo Nogueira Bandeira, Lissiana Magna Vasconcelos Aguiar, Rodrigo Maranguape Silva da Cunha
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引用次数: 0

Abstract

Oxidative stress is related to health problems including neurological and neurodegenerativedisturbs, such as Parkinson's disease. Natural compounds are reported as source of antioxidant molecules. Therefore, this study aimed to analyze the antioxidant and neuroprotective potential of a new diterpene isolated from C. argyrophylloides (MP-1). Male Wistar rats (250-300 g) were used to evaluate MP-1 antiparkinsonian potential through neurodegenerative model induced by the neurotoxin 6-hydroxydopamine (21 μg). On the 14th day, animals were submitted to behavioral tests and on the 15th day, brain areas were dissected to neurochemical analyzes. MP-1 demonstrated a high antioxidant capacity in vitro and decreased the parkinsonian effects, such as behavioral changes, motor alterations, and body weight loss. MP-1 was also able to control the upregulated levels of nitrosative stress and lipid peroxidation. These findings suggest MP-1 as a diterpene with high antioxidant capacity which might be used to development of new approach against Parkinson's disease.

巴豆中一种新的二萜抗氧化和抗帕金森潜能的评价。
氧化应激与健康问题有关,包括神经和神经退行性紊乱,如帕金森病。据报道,天然化合物是抗氧化分子的来源。因此,本研究旨在分析从银叶黄中分离的一种新的二萜(MP-1)的抗氧化和神经保护作用。用雄性Wistar大鼠(250 ~ 300 g)通过神经毒素6-羟多巴胺(21 μg)诱导神经退行性模型评价MP-1的抗帕金森潜能。第14天,动物接受行为测试,第15天,解剖大脑区域进行神经化学分析。MP-1在体外显示出高抗氧化能力,并减少帕金森病的影响,如行为改变、运动改变和体重减轻。MP-1还能够控制亚硝化应激和脂质过氧化的上调水平。这些发现提示MP-1作为一种具有高抗氧化能力的二萜,可能用于开发治疗帕金森病的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Free Radical Research
Free Radical Research 生物-生化与分子生物学
CiteScore
6.70
自引率
0.00%
发文量
47
审稿时长
3 months
期刊介绍: Free Radical Research publishes high-quality research papers, hypotheses and reviews in free radicals and other reactive species in biological, clinical, environmental and other systems; redox signalling; antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; and oxidative damage, mechanisms and measurement.
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