Sublethal Effects of Cadmium on the Osmoregulatory and Acid-Base Parameters of Tilapia (Oreochromis niloticus) at Various Times.

IF 3.4 Q2 TOXICOLOGY
Agoes Soegianto, Bambang Yulianto, Carolyn Melissa Payus, Moch Affandi, Wildanun Mukholladun, Khudrotul Nisa Indriyasari, Ary Marchellina, Nailul Muthiati Rahmatin
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引用次数: 1

Abstract

Background: Cadmium (Cd) can contaminate aquatic environments as a result of anthropogenic activity. Cd accumulates quickly in the tissues of fish and has the potential to affect their physiology, including osmoregulation and acid-base balance. Therefore, the purpose of this study was to examine the sublethal effects of Cd on the osmoregulation and acid-base balance of tilapia Oreochromis niloticus at different times.

Methods: Fish were exposed to sublethal concentrations of Cd (1 and 2 mg/L) for 4 and 15 days. At the end of the experiment, fish were collected from each treatment to examine the levels of Cd and carbonic anhydrase (CA) in the gills, plasma osmolality, ions, blood pH, pCO2, pO2, and hematological parameters.

Results: Cd concentrations in gills rose with increasing Cd concentrations in the medium and exposure time. Cd inhibited respiration by generating metabolic acidosis, decreasing gill CA, reducing pO2, plasma osmolality, Cl-, and K+, particularly at 2 mg/L for 4 days and 1 and 2 mg/L for 15 days. Red blood cell (RBC), hemoglobin (Hb), and hematocrit (Ht) levels decreased as Cd levels in water and exposure duration increased.

Conclusion: Cd inhibits respiration, lowers RCB, Hb, and Ht levels and decreases ionic and osmotic regulation. All of these impairments can limit a fish's ability to provide appropriate oxygen to its cells, hence diminishing its physical activity and productivity.

Abstract Image

Abstract Image

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不同时期镉对罗非鱼渗透调节和酸碱参数的亚致死效应。
背景:镉(Cd)可以污染水生环境的人为活动的结果。镉在鱼的组织中迅速积累,并有可能影响鱼的生理机能,包括渗透调节和酸碱平衡。因此,本研究的目的是研究不同时期镉对尼罗罗非鱼渗透调节和酸碱平衡的亚致死效应。方法:将鱼暴露于亚致死浓度的Cd(1和2 mg/L)中4天和15天。在试验结束时,收集每个处理的鱼,检测鱼鳃中Cd和碳酸酐酶(CA)水平、血浆渗透压、离子、血液pH、pCO2、pO2和血液学参数。结果:鱼鳃中Cd浓度随培养基中Cd浓度和暴露时间的增加而升高。Cd通过产生代谢性酸中毒、降低鳃CA、降低pO2、血浆渗透压、Cl-和K+来抑制呼吸,特别是在2 mg/L持续4天、1和2 mg/L持续15天的情况下。红细胞(RBC)、血红蛋白(Hb)和红细胞压积(Ht)水平随着水中镉含量和暴露时间的增加而降低。结论:Cd抑制呼吸,降低RCB、Hb和Ht水平,降低离子和渗透调节。所有这些损伤都会限制鱼类向细胞提供适当氧气的能力,从而减少其身体活动和生产力。
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来源期刊
Journal of Toxicology
Journal of Toxicology TOXICOLOGY-
CiteScore
5.50
自引率
3.40%
发文量
0
审稿时长
10 weeks
期刊介绍: Journal of Toxicology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of toxicological sciences. The journal will consider articles looking at the structure, function, and mechanism of agents that are toxic to humans and/or animals, as well as toxicological medicine, risk assessment, safety evaluation, and environmental health.
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