Small molecules that enhance mitophagy to delay aging and neurodegeneration.

Abstract

Mitochondria are central arbiters of cell fate. Mitochondrial respiration produces ATP, the chemical fuel for most biological processes in multicellular organisms. Conversely, mitochondrial respiration that is not properly coupled to ATP synthesis produces mito- and cytotoxic reactive oxygen species (ROS) that can damage cell and organelle DNA, protein and lipid, thereby evoking premature cell senescence or programmed death. The dual role of mitochondria as sustainers of cell life vs engines of cell death requires cells to deploy surveillance and removal systems that identify, isolate and selectively