Toxicological Effects of Sudan III Azo Dye in Palm Oil on Liver Enzyme and Non Enzyme Markers of Albino Rat

International Journal of Nutrition and Food Sciences Pub Date : 2020-07-31 DOI:10.11648/j.ijnfs.20200904.12

Nwachoko Ndidi, Odinga Tamuno-boma, Akuru Udiomine Brantley, Ibanibo Tamunomiebam Emmanuel

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引用次数: 3

Abstract

The economic and nutritional value of palm oil has made its utilization to be on the increase especially in Nigeria, thereby making it expensive, hence the temptation to adulterate it by bulk buyers with the wrong assertion of retaining the quality. This study was therefore undertaken to evaluate the effect of adulterated palm oil on the activity of liver enzymes and non-liver enzymes markers of albino rats. Twenty rats divided into five groups of four rats each were used for this investigation for fourteen (14) days. At the end of the experiment, the animals were sacrificed, blood samples were collected for biochemical analysis. Biochemical indices of liver enzymes makers and non-liver markers were determined. Liver enzymes ALP and ALT concentrations showed significant increase (p<0.05) when compared with group 1 and 2, also non-liver markers albumin, conjugated and total bilirubin showed significant increase (p<0.05) when compared to group 1 and 2. Histopathological examination showed mild inflammation of the liver for group 3, while histological features for groups (4 & 5) administered with higher dosage showed intense periportal and intraparenchymal inflammations. A compromise in liver function in rats administered with adulterated palm oil was observed.

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棕榈油中苏丹ⅲ偶氮染料对白化大鼠肝酶和非酶标志物的毒理学影响

棕榈油的经济和营养价值使其利用率不断增加，特别是在尼日利亚，从而使其价格昂贵，因此，散装买家诱惑其掺假，错误地断言保持质量。因此，本研究旨在评估掺假棕榈油对白化大鼠肝酶和非肝酶标志物活性的影响。20只大鼠分为5组，每组4只大鼠，实验时间为14天。实验结束后，处死动物，采集血液进行生化分析。测定肝酶生成物和非肝标志物的生化指标。肝酶ALP和ALT浓度与1、2组相比显著升高(p<0.05)，非肝脏标志物白蛋白、偶联胆红素和总胆红素浓度与1、2组相比显著升高(p<0.05)。组织病理学检查显示，3组肝脏轻度炎症，而高剂量组(4和5)的组织学表现为强烈的门静脉周围和肝实质内炎症。观察到掺假棕榈油对大鼠肝功能的损害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Nutrition and Food Sciences

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