Advances on the etiology of bubble formation mechanism of altitude decompression sickness

中华航空航天医学杂志 Pub Date : 2019-03-15 DOI:10.3760/CMA.J.ISSN.1007-6239.2019.01.015

Xiaohui Zheng, Qinglin Zhou, Zhaoli Ge, Feifei Wu

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Abstract

Objective To investigate the new research solutions on special environmental medicine by discussing the etiology of bubble formation mechanism in the basic researches of altitude decompression. Literature resource and selection Research papers and literature reviews published at home and abroad. Literature quotation Fifty-eight published papers and reviews were cited. Literature synthesis The role of air nucleus, the precursors of bubbles, in the etiology of decompression sickness was reviewed and analyzed including the normal existence of air nucleus in vivo, the mechanism of its formation and stable existence. At present, there is no definite conclusion on above three aspects and the researches are still facing the challenge. In addition, the relationship between bubble formation and pathological manifestations of decompression sickness, the effect of movement on bubble formation, the methodology of micro-bubble study in vivo, the role of patent foramen ovale in the pathogenesis of neuropathic decompression sickness, and the relationship and significance between bubble study in vivo and some subjects related to clinical medicine were discussed. The scope of this paper covers the main issues in the basic research of altitude decompression sickness, and has certain reference significance for understanding and planning the future research direction in this field. Conclusions With the help of interdisciplinary integration, the etiological study of decompression sickness is expected to make substantial breakthroughs and the research and development of special environmental medicine will have a new direction of solution. Key words: Altitude; Decompression sickness; Bubble; Gas nucleus; Review

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高原减压病气泡形成机制的病因学研究进展

目的探讨高原减压基础研究中气泡形成机制的病因，探讨特殊环境医学研究的新思路。文献资源与选择国内外发表的研究论文和文献综述。文献引用共引用论文、综述58篇。综述并分析了气泡前体空气核在减压病发病中的作用，包括空气核在体内的正常存在、形成机制及稳定存在。目前，以上三个方面都没有明确的结论，研究还面临着挑战。此外，还讨论了气泡形成与减压病病理表现的关系、运动对气泡形成的影响、体内微气泡研究的方法学、卵圆孔未闭在神经性减压病发病机制中的作用以及体内气泡研究与临床医学相关课题的关系和意义。本文的研究范围涵盖了高原减压病基础研究中的主要问题，对认识和规划该领域未来的研究方向具有一定的参考意义。结论在多学科融合的帮助下，减压病的病因学研究有望取得实质性突破，特种环境医学的研发也将有新的解决方向。关键词:海拔;减压病;泡沫;气核;审查

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来源期刊

中华航空航天医学杂志航空航天医学

自引率

0.00%

发文量

2962

期刊介绍： The aim of Chinese Journal of Aerospace Medicine is to combine theory and practice, improve and popularize, actively advocate a hundred flowers bloom and a hundred schools of thought contend, advocate seeking truth from facts, promote the development of the related disciplines of aerospace medicine and human efficiency, and promote the exchange and penetration of aerospace medicine and human efficiency with other biomedical and engineering specialties. Topics of interest for Chinese Journal of Aerospace Medicine include: -The content of the journal belongs to the discipline of special medicine and military medicine, with the characteristics of multidisciplinary synthesis and cross-penetration, and mainly reflected in the aerospace industry, aerospace flight safety and efficiency, as well as the synthesis of special medicine, preventive medicine, environmental medicine, psychology, etc. -Military aeromedicine (Air Force, Navy and Army aeromedicine) and civil aeromedicine, with a balance of aerospace medicine are the strengths of the journal. -The change in aerospace medicine from a focus on promoting physiological compensatory adaptations to enhancing human performance under extreme environmental conditions is what the journal is helping to promote. -The expansion of manuscripts in high altitude medicine is also a special emphasis of the journal.