State of the art in assisted reproductive technologies for patients with advanced maternal age.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-04-01 DOI:10.1017/S0967199422000624

Taisiia Yurchuk, Marina Petrushko, Barry Fuller

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引用次数: 1

Abstract

According to the World Health Organization, the female reproductive age lasts up to 49 years, but problems with the realization of women's reproductive rights may arise much earlier. Significant numbers of factors affect the state of reproductive health: socioeconomic, ecological, lifestyle features, the level of medical literacy, and the state of the organization and medical care quality. Among the reasons for fertility decline in advanced reproductive age are the loss of cellular receptors for gonadotropins, an increase in the threshold of sensitivity of the hypothalamic-pituitary system to the action of hormones and their metabolites, and many others. Furthermore, negative changes accumulate in the oocyte genome, reducing the possibility of fertilization, normal development and implantation of the embryo and healthy offspring birth. Another theory of ageing causing changes in oocytes is the mitochondrial free radical theory of ageing. Taking into account all these age-related changes in gametogenesis, this review considers modern technologies aimed at the preservation and realization of female fertility. Among the existing approaches, two main ones can be distinguished: methods allowing the preservation of reproductive cells at a younger age using ART intervention and cryobanking, as well as methods aimed at improving the basic functional state of advanced-age women's oocytes and embryos.

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高龄产妇辅助生殖技术的最新进展。

根据世界卫生组织的资料，女性的生育年龄最长可达49岁，但实现妇女生殖权利方面的问题可能出现得更早。影响生殖健康状况的因素有很多:社会经济、生态、生活方式特点、医学知识水平、组织状况和医疗质量。高龄生育导致生育能力下降的原因包括促性腺激素细胞受体的丧失，下丘脑-垂体系统对激素及其代谢物作用的敏感性阈值的增加，以及许多其他因素。此外，卵母细胞基因组的负面变化积累，降低了受精、胚胎正常发育和着床以及后代健康出生的可能性。衰老引起卵母细胞变化的另一个理论是线粒体自由基衰老理论。考虑到配子体发生中所有这些与年龄相关的变化，本文综述了旨在保存和实现女性生育能力的现代技术。在现有的方法中，可以区分出两种主要的方法:一种是通过ART干预和冷冻银行在年轻时保存生殖细胞的方法，另一种是旨在改善高龄女性卵母细胞和胚胎的基本功能状态的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.