Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study".

Q1 Medicine

Wellcome Open Research Pub Date : 2024-10-11 eCollection Date: 2021-01-01 DOI:10.12688/wellcomeopenres.16778.3

Thomas C Williams, Steve Cunningham, Simon B Drysdale, Helen Groves, Dalia Iskander, Xinxue Liu, Mark D Lyttle, Robin Marlow, Abigail Maxwell-Hodkinson, Chengetai D Mpamhanga, Shaun O'Hagan, Ian Sinha, Olivia V Swann, Thomas Waterfield, Damian Roland

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引用次数: 0

Abstract

Background: In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.

Study question: We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.

Methods and likely impact: We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.

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BronchStart - COVID-19 大流行对呼吸道合胞病毒 (RSV) 急诊发病的时间、年龄和严重程度的影响；一项多中心前瞻性观察队列研究 "的研究预案。

背景：支气管炎（最常由呼吸道合胞病毒（RSV）引起）是一种常见的冬季疾病，主要影响一岁以下儿童。它是急诊科（ED）的常见病，经常导致入院治疗，每年冬季都会导致儿科病房接近或超过饱和状态。在 SARS-CoV-2 大流行期间，RSV 在英国和爱尔兰的传播急剧减少。来自南半球和其他欧洲国家的证据表明，随着对 SARS-CoV-2 的社会隔离限制的放宽，RSV 感染又会卷土重来，造成延迟流行甚至夏季流行，并呈现出不同的年龄分布。研究问题：跟踪、预测和应对 RSV 病例激增的能力对于规划急性护理服务至关重要。我们迫切需要尽早了解 RSV 传播的起始时间。这将影响服务规划，使临床医生了解高危人群的年龄范围是否大于正常范围，以及疾病严重程度是否发生变化。还需要这些信息来决定对感染 RSV 后住院、入住重症监护室或死亡风险较高的儿童进行被动免疫的时间，这是公共卫生的优先事项。方法和可能的影响：这项多中心前瞻性观察性队列研究将利用一个完善的研究网络（英国和爱尔兰儿科急诊研究，PERUKI），通过收集重要的但不能识别患者身份的信息，实时报告两岁以下儿童感染 RSV 的病例。45 个中心将收集有关年龄、多重贫困指数五分位数、发病时的临床特征和并发症的初始数据。每个病例将在七天后进行随访，以确定治疗、病毒诊断和结果。信息每周发布一次，用于支持临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wellcome Open Research Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

5.50

自引率

0.00%

发文量

426

审稿时长

1 weeks

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