Effect of Extra Panadol on Blood and Behavior of Rats

Abstract

Aim: To study the effect of Panadol extra on blood and behavior of rats. Methods: Locally bred male albino Wister rats weighing about 145 to 155 g on arrival purchased from animal house, research institute of Agha Khan University Karachi Pakistan were used throughout the experiments. Total of 24 rats were grouped into two: 12 rats called control and 12 test group. Normal saline was given to control while, 500 mg/tablet (extra Panadol) into 30 mg/kg body weight was dissolved in water and was given to rats. Behavioral study was observed. After 3 weeks of treatment rats were decapitated. Automated Hematology Analyzer SYSMEX XP 100 and Biochemical analyzer the Roche/Hitachi 902 was used for liver enzymes and hematological analysis. Results: Panadol extra has no effect on locomotor activity and the effect of stimulatory activity of rats increases. Depression and anxiety of rats decreases and at the same time it is useful to enhance memory. Hematological parameters and liver enzymes were also non-significantly decreased in test group of rats as compare to control group. Panadol extra is considered a good choice of drug and its side effects are very rare if it is used properly but by frequent and prolonged or excessive use of Panadol extra rats become unable to Fight against diseases and it also highly significantly decreases the PLT count by which their blood clotting mechanism is highly disturbed. Conclusion: Present study concludes that this drug may be used to enhance memory and decrease anxiety and depression for good performance.