Efficacy of Ilex paraguariensis versus Placebo on Lipid Profile in Randomized Clinical Trial: A Systematic Review and Meta-analysis

Mirna Clemente, A. Wiens, M. Miguel, K. Felipe, E. F. Clemente, Caroline Gribner, C. B. Schonhofen, O. Miguel
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引用次数: 1

Abstract

Copyright © 2020 Phcog.Net. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 International license. ABSTRACT Introduction: The use of medicinal plants have been increasing progressively around the world and been associated with decreasing Total Cholesterol (TC) and Low-Density LipoproteinCholesterol (LDL-C) and, increasing High-Density Lipoprotein-Cholesterol (HDL-C) in humans. Ilex paraguariensis, known as yerba mate, is rich in bioactive compounds, especially chlorogenic acid has been shown as one of the major contributor to hypocholesterolemic. This review aimed to demonstrate if Ilex paraguariensis supplementation is more effective than placebo on lipid profile in randomized placebo-controlled trial. Methods: A careful search was performed in PubMed, Web of Science, SciELO, Scopus and Cochrane Library, published until May 2020. The following keywords of Medical Sub Headings (MeSH) were used as search terms: (“yerba mate” OR “Ilex paraguariensis”) AND (“dyslipidemia” OR “hyperlipidemia”) AND (“clinical trial” OR “Randomized Controlled Trial (RCT)” OR “randomly”). Results: The literature search identified 149 “Ilex paraguariensis x clinical trials”, 16 full-text assessed. After, following the inclusion and exclusion criteria, only 3 studies were chosen to qualitative and quantitative synthesis. The study showed that Ilex paraguariensis could improve HDL-C, but with no differences in TC and triglycerides, comparing to placebo-controlled group. Conclusion: The three included clinical trials have demonstrated high quality, low bias and HDL-C statistically different. To validate the last result, more clinical trials interventions are necessary, Although TC and triglycerides did not demonstrated differences statistically and increasing HDL-C may improve or protect the metabolism of lipid profile, after been supplemented by Ilex paraguariensis, compared to placebo-controlled trial.
巴拉圭冬青与安慰剂在随机临床试验中对血脂的疗效:系统评价和荟萃分析
版权所有©2020 Phcog.Net这是一篇基于知识共享署名4.0国际许可协议的开放获取文章。摘要简介:药用植物的使用在世界范围内逐渐增加,并与降低人类总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)以及增加高密度脂蛋白胆固醇(HDL-C)有关。巴拉圭冬青,被称为马黛茶,富含生物活性化合物,特别是绿原酸已被证明是降低胆固醇的主要因素之一。本综述旨在证明在随机安慰剂对照试验中,巴拉圭冬青补充剂是否比安慰剂更有效。方法:在PubMed、Web of Science、SciELO、Scopus和Cochrane Library中进行仔细搜索,检索截止到2020年5月。使用医学副标题(MeSH)的以下关键词作为搜索词:(“马茶”或“巴拉圭冬青”)和(“血脂异常”或“高脂血症”)和(“临床试验”或“随机对照试验”或“随机”)。结果:检索到文献149篇“巴拉圭冬青x临床试验”,评估了16篇全文。之后,按照纳入和排除标准,仅选择3项研究进行定性和定量综合。研究表明,巴拉圭冬青可以改善HDL-C,但与安慰剂对照组相比,TC和甘油三酯没有差异。结论:3项纳入的临床试验均具有高质量、低偏倚和HDL-C差异的统计学意义。为了验证最后的结果,需要更多的临床试验干预,尽管TC和甘油三酯在统计学上没有表现出差异,并且与安慰剂对照试验相比,巴拉圭冬青补充后增加HDL-C可能改善或保护脂质代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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