A Prospective Study of Mid-Trimester MCP-1 Levels as a Predictor of Preterm Delivery.

Medicines (Basel, Switzerland) Pub Date : 2022-12-30 DOI:10.3390/medicines10010007

Mirjana A Bogavac, Dejan D Ćelić, Tamara M Perić

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Abstract

Background: The prevention of preterm delivery (PTD) represents one of the major topics in modern obstetrics. The aim was to design a prospective study and investigate if mid-trimester serum and amniotic fluid levels of MCP-1 could predict the occurence of spontaneous PTD. Methods: The study involved 198 women who underwent genetic amniocentesis and blood sampling in the middle of their trimester. After applying the criteria for inclusion in the study, there were 16 respondents in the study group, and 38 respondents in the control group. Level of MCP-1 in amniotic fluid and serum was measured with commercially available enzyme-linked immunosorbent assays (ELISA) and statistical analysis was conducted. Results: There was no statistically significant difference in serum or amniotic fluid MCP1 levels between PTD and the control groups. Conclusion: The results suggest that MCP-1 is probably not the most relevant marker for predicting PTD. This study provides new normative data for MCP-1 levels in amniotic fluid and maternal sera and is a valuable tool for future diagnostic and comparative studies.

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妊娠中期MCP-1水平作为早产预测因子的前瞻性研究。

背景:预防早产(PTD)是现代产科的主要课题之一。目的是设计一项前瞻性研究，探讨妊娠中期血清和羊水MCP-1水平是否可以预测自发性PTD的发生。方法:该研究涉及198名在妊娠中期进行遗传羊膜穿刺术和血液取样的妇女。应用纳入标准后，研究组有16名应答者，对照组有38名应答者。采用市售酶联免疫吸附法(ELISA)检测羊水和血清中MCP-1水平，并进行统计学分析。结果:PTD患者血清及羊水MCP1水平与对照组比较，差异无统计学意义。结论:结果提示MCP-1可能不是预测PTD最相关的标志物。本研究为羊水和产妇血清中MCP-1水平的测定提供了新的规范数据，为今后的诊断和比较研究提供了有价值的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medicines (Basel, Switzerland)

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审稿时长

6 weeks