Extracellular vesicles derived from mesenchymal stem cells - a novel therapeutic tool in infectious diseases.

IF 5 3区医学 Q2 IMMUNOLOGY

Inflammation and Regeneration Pub Date : 2023-02-28 DOI:10.1186/s41232-023-00266-6

Tasaduq Manzoor, Afnan Saleem, Nida Farooq, Lateef Ahmad Dar, Junaid Nazir, Sahar Saleem, Sameena Ismail, Mudasir Bashir Gugjoo, Parvaiz A Shiekh, Syed Mudasir Ahmad

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引用次数: 9

Abstract

Extracellular vesicles (EVs) are nano-sized lipid-bilayer encapsulated vesicles produced by the cells. These EVs are released into the surrounding space by almost all cell types. The EVs help in intercellular communication via their payloads which contain various proteins, lipids, and nucleic acids generated from the donor cells and allow for synergistic responses in surrounding cells. In recent years, EVs have been increasingly important in treating infectious diseases, including respiratory tract infections, urinary tract infections, wound infections, sepsis, and intestinal infections. Studies have confirmed the therapeutic value of mesenchymal stem cell-derived EVs (MSC-EVs) for treating infectious diseases to eliminate the pathogen, modulate the resistance, and restore tissue damage in infectious diseases. This can be achieved by producing antimicrobial substances, inhibiting pathogen multiplication, and activating macrophage phagocytic activity. Pathogen compounds can be diffused by inserting them into EVs produced and secreted by host cells or by secreting them as microbial cells producing EVs carrying signalling molecules and DNA shielding infected pathogens from immune attack. EVs play a key role in infectious pathogenesis and hold great promise for developing innovative treatments. In this review, we discuss the role of MSC-EVs in treating various infectious diseases.

Abstract Image

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间充质干细胞衍生的细胞外囊泡——感染性疾病的新治疗工具。

细胞外囊泡(EVs)是由细胞产生的纳米级脂质双层囊泡。这些电动汽车被几乎所有类型的电池释放到周围的空间。ev通过其含有供体细胞产生的各种蛋白质、脂质和核酸的有效载荷帮助细胞间通信，并允许周围细胞的协同反应。近年来，ev在呼吸道感染、尿路感染、伤口感染、败血症和肠道感染等感染性疾病的治疗中发挥着越来越重要的作用。研究证实了间充质干细胞衍生的ev (msc - ev)在感染性疾病中具有消灭病原体、调节抵抗、修复组织损伤等治疗价值。这可以通过产生抗菌物质、抑制病原体增殖和激活巨噬细胞吞噬活性来实现。病原体化合物可以通过将其插入宿主细胞产生和分泌的ev中或将其作为微生物细胞分泌，产生携带信号分子和DNA的ev，以保护受感染的病原体免受免疫攻击。ev在感染发病机制中发挥着关键作用，在开发创新治疗方法方面具有很大的前景。本文就msc - ev在治疗多种感染性疾病中的作用进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.