Analytical approaches and preparation of biological, food and environmental samples for analyses of zearalenone and its metabolites

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Reviews in Analytical Chemistry Pub Date : 2020-01-01 DOI:10.1515/revac-2020-0105

R. Gadzała-Kopciuch, Anna Kuźniewska, B. Buszewski

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引用次数: 3

Abstract

Abstract Zearalenone (ZEN) is a mycotoxin that occurs in all stages of plant growth and development and exerts harmful effects on humans and animals. Zearalenone is easily absorbed in the digestive tract, and it is metabolized in the intestinal wall and the liver. Zearalenone has several derivatives: zearalenone, zearalanone (ZAN), α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), α-zearalanol (α-ZAL) and β-zearalanol (β-ZAL). These substances have a high affinity for estrogen receptors, and they can gradually affect the endocrine system. Excess ZEN and its metabolites are excreted with urine and bile. This paper analyzes ZEN metabolism and investigates the presence of ZEN and its metabolites in urine. Since the isolation of ZEN and its metabolites from different matrices still poses a significant problem, the paper also presents various sample preparation methods (including liquid-solid extraction, liquid-liquid extraction and other techniques) as well as sensitive and specific chromatographic techniques, including liquid chromatography (LC) with fluorescence and mass spectrometry detection, gas chromatography (GC) and thin-layer chromatography (TLC).

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玉米赤霉烯酮及其代谢物分析用生物、食品和环境样品的分析方法和制备

玉米赤霉烯酮(ZEN)是一种真菌毒素，存在于植物生长发育的各个阶段，对人类和动物都有危害。玉米赤霉烯酮易被消化道吸收，并在肠壁和肝脏代谢。玉米赤霉烯酮有几种衍生物:玉米赤霉烯酮、玉米赤霉烯酮(ZAN)、α-玉米赤霉烯醇(α-ZEL)、β-玉米赤霉烯醇(β-ZEL)、α-玉米赤霉烯醇(α-ZAL)和β-玉米赤霉烯醇(β-ZAL)。这些物质对雌激素受体有很高的亲和力，可以逐渐影响内分泌系统。过量的ZEN及其代谢物随尿液和胆汁排出。本文分析了ZEN的代谢，探讨了ZEN及其代谢物在尿液中的存在。由于从不同基质中分离ZEN及其代谢物仍然是一个重大问题，本文还介绍了各种样品制备方法(包括液固萃取、液液萃取等技术)以及敏感和特异性色谱技术，包括荧光和质谱检测的液相色谱(LC)、气相色谱(GC)和薄层色谱(TLC)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in Analytical Chemistry 化学-分析化学

CiteScore

7.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.