Emerging roles of circular RNAs in the invasion and metastasis of head and neck cancer: Possible functions and mechanisms

Cancer Innovation Pub Date : 2023-02-19 DOI:10.1002/cai2.50
Shouyi Tang, Luyao Cai, Zhen Wang, Dan Pan, Qing Wang, Yingqiang Shen, Yu Zhou, Qianming Chen
{"title":"Emerging roles of circular RNAs in the invasion and metastasis of head and neck cancer: Possible functions and mechanisms","authors":"Shouyi Tang,&nbsp;Luyao Cai,&nbsp;Zhen Wang,&nbsp;Dan Pan,&nbsp;Qing Wang,&nbsp;Yingqiang Shen,&nbsp;Yu Zhou,&nbsp;Qianming Chen","doi":"10.1002/cai2.50","DOIUrl":null,"url":null,"abstract":"<p>Head and neck cancer (HNC) is the seventh most prevalent malignancy worldwide in 2020. Cancer metastasis is the main cause of poor prognosis in HNC patients. Recently, circular RNAs (circRNAs), initially thought to have no biological function, are attracting increasing attention, and their crucial roles in mediating HNC metastasis are being extensively investigated. Existing studies have shown that circRNAs primarily function through miRNA sponges, transcriptional regulation, interacting with RNA-binding proteins (RBPs) and as translation templates. Among these functions, the function of miRNA sponge is the most prominent. In this review, we summarized the reported circRNAs involved in HNC metastasis, aiming to elucidate the regulatory relationship between circRNAs and HNC metastasis. Furthermore, we summarized the latest advances in the epidemiological information of HNC metastasis and the tumor metastasis theories, the biogenesis, characterization and functional mechanisms of circRNAs, and their potential clinical applications. Although the research on circRNAs is still in its infancy, circRNAs are expected to serve as prognostic markers and effective therapeutic targets to inhibit HNC metastasis and significantly improve the prognosis of HNC patients.</p>","PeriodicalId":100212,"journal":{"name":"Cancer Innovation","volume":"2 6","pages":"463-487"},"PeriodicalIF":0.0000,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cai2.50","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Innovation","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cai2.50","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Head and neck cancer (HNC) is the seventh most prevalent malignancy worldwide in 2020. Cancer metastasis is the main cause of poor prognosis in HNC patients. Recently, circular RNAs (circRNAs), initially thought to have no biological function, are attracting increasing attention, and their crucial roles in mediating HNC metastasis are being extensively investigated. Existing studies have shown that circRNAs primarily function through miRNA sponges, transcriptional regulation, interacting with RNA-binding proteins (RBPs) and as translation templates. Among these functions, the function of miRNA sponge is the most prominent. In this review, we summarized the reported circRNAs involved in HNC metastasis, aiming to elucidate the regulatory relationship between circRNAs and HNC metastasis. Furthermore, we summarized the latest advances in the epidemiological information of HNC metastasis and the tumor metastasis theories, the biogenesis, characterization and functional mechanisms of circRNAs, and their potential clinical applications. Although the research on circRNAs is still in its infancy, circRNAs are expected to serve as prognostic markers and effective therapeutic targets to inhibit HNC metastasis and significantly improve the prognosis of HNC patients.

Abstract Image

环状 RNA 在头颈癌的侵袭和转移中的新作用:可能的功能和机制
头颈癌(HNC)是 2020 年全球第七大高发恶性肿瘤。癌症转移是导致 HNC 患者预后不良的主要原因。近来,最初被认为没有生物学功能的环状 RNA(circRNA)正引起越来越多的关注,它们在介导 HNC 转移中的关键作用正受到广泛研究。现有研究表明,circRNAs 主要通过 miRNA 海绵、转录调控、与 RNA 结合蛋白(RBPs)相互作用以及作为翻译模板发挥作用。在这些功能中,miRNA 海绵的功能最为突出。在这篇综述中,我们总结了已报道的参与HNC转移的circRNAs,旨在阐明circRNAs与HNC转移之间的调控关系。此外,我们还总结了HNC转移的流行病学信息和肿瘤转移理论、circRNAs的生物发生、表征和功能机制及其潜在的临床应用等方面的最新进展。尽管对circRNAs的研究仍处于起步阶段,但circRNAs有望作为预后标志物和有效的治疗靶点,抑制HNC转移,显著改善HNC患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
0.70
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信