Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests

Aleksandra Miłos, Marcin Gackowski, A. Przybylska, Piotr Kośliński, M. Koba
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Abstract

Drug addiction is a disease that is characterized by a compulsion, a desire to take different substances permanently or for a certain period of time. Numerous negative incidents, such as crimes, work accidents and traffic accidents, are related to using illegal substances. Therefore, urine drug cassette tests have become a screening tool. However, considering legal consequences of test result, the question arises of their performance and reliability. On this account, the main objective of this study was to evaluate the sensitivity and specificity of urine drug tests available on the commercial pharmaceutical market. Evaluated tests were immersed in synthetic urine diluent spiked with amphetamine at various concentrations also containing potentially interfering substances such as caffeine, paracetamol and acetylsalicylic acid, and after a certain period of time, it was observed whether the result was as expected. The reference method used in this study was high-performance liquid chromatography. The obtained results confirmed the declared cut-off as well as specificity of rapid diagnostic tests.
商用安非他明试验的敏感性和特异性比较
药物成瘾是一种疾病,其特征是强迫、渴望永久或在一段时间内服用不同的物质。许多负面事件,如犯罪、工作事故和交通事故,都与使用非法物质有关。因此,尿药盒试验已成为一种筛查工具。然而,考虑到测试结果的法律后果,就产生了它们的性能和可靠性问题。因此,本研究的主要目的是评估商业药品市场上可用的尿液药物测试的敏感性和特异性。被评估的测试对象浸泡在含有不同浓度安非他明的合成尿液稀释剂中,该稀释剂还含有咖啡因、扑热息痛和乙酰水杨酸等潜在干扰物质,并在一段时间后观察结果是否如预期的那样。本研究的参比方法为高效液相色谱法。所获得的结果证实了所宣布的截止日期以及快速诊断试验的特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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