Fabrication and characterization of fast dissolving films of H2-receptor antagonist

Abstract

Objective: The aim of the present study was to develop a fast dissolving film (FDF) of taste masked inclusioncomplex of Famotidine (FMT) using film forming polymer. Method: FDFs were prepared by solvent castingmethod. The developed FDFs were characterized for film thickness, disintegration time, flexibility, dissolutionstudy. The developed FDFs of FMT were transparent, elegant, smooth and homogenous. Results: Physicochemicalcharacterization of FDFs showed no interaction between the drug and film forming polymer. The drug content wasfound in the range of 96.05 to 102% and disintegration time was found in pharmacopoeia limit, which was less than1 min. In vitro drug release study showed that approximately 82% drug release within 60 sec. Conclusion: Fast Dissolving film of famotidine is prepared that dissolve within one minute when placed on tongue. It gives fact actionbecause it avoids the first pass metabolism. These films are preferred in geriatric and pediatric patients.