Investigating Body Mass Index and Body Composition in Patients with Schizophrenia: A Case-Control Study

IF 3.6 Q1 PSYCHIATRY
M. Marthoenis, M. Martina, Rudi Alfiandi, D. Dahniar, Rini Asnurianti, H. Sari, Jacqueline Nassimbwa, S. Arafat
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引用次数: 3

Abstract

Background Antipsychotics exert metabolic side effects, and prolonged treatment with antipsychotics causes changes in body weight and muscle composition. Nevertheless, reports on the changes in body composition of patients with schizophrenia have been limited. This study is aimed at comparing the body mass index and body composition of patients with schizophrenia with healthy individuals in Indonesia. Methods A total of 195 patients with schizophrenia (148 males and 47 females) and 195 healthy individuals matched by gender were recruited. Using the Bioelectrical Impedance Analysis method, the participants' body compositions were measured. Results Compared to healthy individuals, the patient group exhibited a higher rate of underweight as well as a lower rate of overweight and obesity. Multiple regression analysis confirmed the associations between the body mass index and all measured body compositions. Furthermore, the diagnosis of schizophrenia is significantly associated with lower muscle mass, lower bone mass, higher basal metabolic rate, older metabolic age, and higher total body water. Conclusions The results showed that patients with schizophrenia are at a greater risk of a lower quality of certain components of body composition. Priority should be given to research that addresses increasing the patient's level of physical activity.
调查精神分裂症患者的身体质量指数和身体成分:一项病例对照研究
背景:抗精神病药物会产生代谢副作用,长期服用抗精神病药物会导致体重和肌肉成分的变化。然而,关于精神分裂症患者身体成分变化的报道有限。本研究旨在比较印度尼西亚精神分裂症患者与健康人的身体质量指数和身体成分。方法共招募195例精神分裂症患者(男148例,女47例)和195名按性别匹配的健康人。采用生物电阻抗分析方法,测量参与者的身体成分。结果与健康个体相比,患者组表现出更高的体重不足率,以及更低的超重和肥胖率。多元回归分析证实了身体质量指数与所有测量的身体成分之间的关联。此外,精神分裂症的诊断与较低的肌肉量、较低的骨量、较高的基础代谢率、较老的代谢年龄和较高的全身水分显著相关。结论精神分裂症患者身体成分中某些成分质量较差的风险较大。应该优先研究如何提高病人的体力活动水平。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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