Amitriptyline and Sertraline in Diabetic Neuropathy: A Comparative View

Abstract

Purpose: To investigate the effect of amitriptyline (Ami) and sertraline (Sert) in diabetes neuropathy. Methods: Diabetes was induced in 3 groups of rats (n=6) with streptozotocin (STZ, 55mg/kg, i.p.). Two of the groups of diabetic rats received amitriptyline (15 mg/kg, p.o) and sertraline (30 mg/kg, p.o.) while another 2 groups (n=6) received the same drug treatment without prior administration of STZ. A normal group (n=6) of rats and STZ-induced group (n=6) of diabetic rats served as controls. The blood glucose, glycosylated hemoglobin (GHb), pain sensitivity and neuromuscular strength in all the rats were determined. Results: Ami (15mg/kg, p.o.) produced severe hyperglycemia (p Keywords: Amitriptyline; sertraline; diabetic neuropathy; glycosylated haemoglobin (GHb); streptozotocin-induced diabetes.