A Review of Antifungal Activities of Ziziphora clinopodioides

Abstract

Ziziphora clinopodioides, also known with vernacular names such as Kakuti-e kuhi, Pinah kuhi, Ankh, Lip vanilla, and mountain mint, is a wild flowering plant that belongs to the Lamiaceae family. It is used in treating typhoid fever, stomach strengthening, abdominal pains, inflammatory and cardiovascular disease, asthma, cough, bronchitis, insomnia, colds, flu, and other infectious diseases in traditional medicine. Additionally, Z. clinopodioides has various biological activities, including antibacterial, antimicrobial, anti-inflammatory, antioxidant, appetizer, carminative, antiseptic, and wound-healing properties. In this study, the antifungal activities of Z. clinopodioides were summarized. The Keywords were searched in Scopus until 19 October 2021 and the articles that contain relevant information about the antifungal activity of Z. clinopodioides were included. Z. clinopodioides leaf and aerial parts had significant antifungal activity against Aspergillus flavus, Aspergillus parasiticus, Candida albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton schoenleini. In some studies, its effects were higher than standards (such as amphotericin B, fluconazole, nystatin, and terbinafine). Therefore, it seems that Z. clinopodioides can be a good choice for more experimental and clinical studies as an antifungal agent.