CNR2 rs2229579 and COMT Val158Met variants, but not CNR2 rs2501432, IL-17 rs763780 and UCP2 rs659366, contribute to susceptibility to substance use disorder in the Turkish population

IF 0.5 4区医学 Q4 PHARMACOLOGY & PHARMACY

Psychiatry and Clinical Psychopharmacology Pub Date : 2019-10-02 DOI:10.1080/24750573.2019.1688030

S. Kurnaz, A. Yazıcı, A. Nursal, P. Çetinay Aydın, Ayca Ongel Atar, N. Aydın, Zeliha Kıncır, S. Pehlivan

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引用次数: 2

Abstract

ABSTRACT OBJECTIVE: Substance use disorders (SUD) are among the most important public health problems throughout the world. We investigated whether COMT (Val108/158Met), CNR2 (rs2501432 and rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants were associated with SUD and its clinical parameters in a Turkish population. METHODS: We conducted a case–control study among 136 subjects with SUD and 100 healthy controls. Six variants were analysed by the PCR-RFLP method. RESULTS: The CNR2 rs2229579 T/T genotype and T allele increased in SUD groups than controls while the C/C genotype and C allele were more prevalent in the control group compared to the SUD group (p = 0.000 and p = 0.001, respectively). The COMT Val108/158Met Val/Val genotype and Val allele were significantly associated with polysubstance abuse (p < 0.05). There was no significant difference between the SUD group and control group regarding genotype and allele frequencies of COMT (Val108/158Met), CNR2 (rs2501432), UCP2 (rs659366) and IL-17 (rs763780) variants. CONCLUSIONS: This is the first study that discussed the relation of these variants and SUD patients in the Turkish population. The results of the analysis indicated that the CNR2 rs2229579 variant has an effect on susceptibility to SUD, suggesting that this variant might play a role in the physiopathology of SUD. The COMT Val108/158Met variant might be an important factor affecting polysubstance use.

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CNR2 rs2229579和COMT Val158Met变异与土耳其人群物质使用障碍易感性有关，而CNR2 rs2501432、IL-17 rs763780和UCP2 rs659366与物质使用障碍易感性无关

摘要目的:物质使用障碍(SUD)是全球最重要的公共卫生问题之一。我们在土耳其人群中调查了COMT (Val108/158Met)、CNR2 (rs2501432和rs2229579)、UCP2 (rs659366)和IL-17 (rs763780)基因变异是否与SUD及其临床参数相关。方法:对136例SUD患者和100名健康对照者进行病例对照研究。采用PCR-RFLP方法对6个变异进行分析。结果:CNR2 rs2229579 T/T基因型和T等位基因在SUD组中较对照组升高，C/C基因型和C等位基因在对照组中较SUD组高(p = 0.000和p = 0.001)。COMT Val108/158Met Val/Val基因型和Val等位基因与多药物滥用有显著相关性(p < 0.05)。在COMT (Val108/158Met)、CNR2 (rs2501432)、UCP2 (rs659366)和IL-17 (rs763780)变异的基因型和等位基因频率方面，SUD组与对照组差异无统计学意义。结论:这是第一个讨论这些变异与土耳其人群中SUD患者关系的研究。分析结果表明，CNR2 rs2229579变异对SUD易感性有影响，提示该变异可能在SUD的生理病理过程中发挥作用。COMT Val108/158Met变异可能是影响多物质使用的重要因素。

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来源期刊

Psychiatry and Clinical Psychopharmacology Medicine-Psychiatry and Mental Health

CiteScore

1.00

自引率

14.30%

发文量

期刊介绍： Psychiatry and Clinical Psychopharmacology aims to reach a national and international audience and will accept submissions from authors worldwide. It gives high priority to original studies of interest to clinicians and scientists in applied and basic neurosciences and related disciplines. Psychiatry and Clinical Psychopharmacology publishes high quality research targeted to specialists, residents and scientists in psychiatry, psychology, neurology, pharmacology, molecular biology, genetics, physiology, neurochemistry, and related sciences.