Deep Eutectic Solvent [DES] Mediated Multicomponent Synthesis of 4-thiazolidinone-5-carboxylic acid: A Green Chemistry Approach

Abstract

The 4-thiazolidinone-5-carboxylic acid and its derivatives are having diverse applications in agriculture, industrial and pharmaceutical fields. Therefore the synthesis of this heterocyclic compound attracted the much attention of researchers with green chemistry protocols. In this research work we have introduced the green protocol for synthesis of 4-thiazolidinone-5-carboxylic acid by keeping the parameters in mind like cost effective, environmentally benign, short reaction time and easy work-up procedure. Initially we have irradiated the mixture of substituted aldehyde, thiosemicarbazide and furan 2-5-dione in the presence of choline chloride-thiourea based Deep Eutectic Solvent [DES] as green medium. The reaction optimization was performed in different solvents like ethanol, glycerol, and PEG-400. The DES which was used as green solvent, produced excellent result in context to short reaction time, yield, easy workup, mild reaction condition and cost effective protocol. All the results are discussed. The DES-mediated synthesis of 4-thiazolidinone-5-carboxylic acid is found to be excellent protocol which followed green chemistry principles. This method is having specific features like mild reaction condition, environmentally benign, cost effective and easy work-up procedure.