Etiological and pathogenetic mechanisms of forming muscle dystonias

Abstract

This article discusses the issues of muscular dystonia pathogenesis that are relevant to modern medicine, as well as the possibility of using the pathogenetic concept as a substrate to supplement the classification criteria. Reviewing the international publications on etiopathophysiology, genetics and classification, the article summarizes the main mechanisms for the occurrence of a pathological process at different levels of the nervous system. Despite the frequent clinical similarity of the symptoms of various forms of muscular dystonia, these symptoms may be the result of dysfunction of completely different genetic and neurophysiological mechanisms. The article focuses on the importance of studying the etiological and pathogenetic mechanisms and their further implementation in clinical practice in order to develop more accurate treatment techniques aimed at eliminating the specific causes of the development of specific forms of muscular dystonia.