Titrimetric Analysis of Acelofenec Sodium by using Mixed Solvency

Abstract

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/ by/4.0) ABSTRACT Titration is a method of quantitative/chemical analysis which can be used to determine the concentration of a known reactant. Mixed solvency has been widely used to enhance the aqueous solubility of a large number of poorly watersoluble drugs. Various organic solvents like methanol, chloroform, dimethyl formamide and ethanol have been employed for solubilization of poorly watersoluble drugs. Organic solvents because of their higher cost, toxicities and pollution are not used as solvent. In the present investigation a sodium benzoate, sodium citrate, sodium salicylate solution (an economic agent) was employed as a hydrotropic solubilizing agent to solubilize the poorly water-soluble drug aceclofenac for its titrimetric analysis in bulk sample and tablets precluding the use of organic solvent. The proposed method is new, simple, precise and inexpensive. The results of the analysis have been validated statistically. The mean % recoveries were found to be close to 100, indicating the accuracy of the proposed method.