Evolución del conocimiento de la fisiopatología de la enfermedad inflamatoria intestinal

Abstract

Knowledge of the pathogenesis of inflammatory bowel disease has evolved over time. The most accepted hypothesis nowadays supports the fact that inflammatory bowel disease is the result of an aberrant immune response in a genetically susceptible host. The last 2 decades have signified a huge advance in this knowledge coming from different perspectives. The objective of this review is to explore studies that represent a qualitative breakthrough in this area, ranging from the influence of microbiota to advances in genetics and finally systems biology approach.