Real-world data analysis on effectiveness of integrative therapies: A practical guide to study design and data analysis using healthcare databases

IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Ye-Seul Lee, Yoon Jae Lee, In-Hyuk Ha
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引用次数: 0

Abstract

Real world data (RWD) is increasingly used to investigate health outcomes and treatment efficacy in the field of integrative medicine. Due to the fact that the majority of RWDs are not intended for research, their secondary use in research necessitates complex study designs to account for bias and confounding. To conduct a robust analysis of RWD in integrative medicine, a comprehensive study design process that reflects the characteristics of integrative therapies is necessary. In this paper, we present a guide for designing comparative effectiveness RWE research in integrative medicine. We discuss key factors to consider when selecting RWDs for research on integrative medicine. We provide practical steps for developing a research question, formulating the PICOT objectives (population, intervention, comparator, outcome, and time horizon), and selecting and defining covariates with a summary table. Specific study designs are depicted with corresponding diagrams. Finally, data analysis procedures are introduced. We hope this article clarifies the importance of RWE research design and related processes in order to improve the rigor of RWD studies in the field of integrative medicine research.

关于综合疗法有效性的真实世界数据分析:使用医疗保健数据库进行研究设计和数据分析的实用指南
现实世界数据(RWD)越来越多地用于调查健康结果和治疗效果在中西医结合领域。由于大多数rwd不是用于研究,它们在研究中的二次使用需要复杂的研究设计,以考虑偏差和混淆。为了对中西医结合中的RWD进行强有力的分析,一个反映中西医结合治疗特点的综合研究设计过程是必要的。在本文中,我们提出了一个指南,设计比较有效的RWE研究在中西医结合。我们讨论了在选择中西医结合研究的rwd时要考虑的关键因素。我们提供了开发研究问题、制定PICOT目标(人群、干预、比较者、结果和时间范围)以及使用汇总表选择和定义协变量的实际步骤。具体的研究设计用相应的图表来描述。最后介绍了数据分析过程。我们希望本文能阐明RWE研究设计及相关流程的重要性,以提高RWD研究在中西医结合研究领域的严谨性。
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来源期刊
Integrative Medicine Research
Integrative Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
6.50
自引率
2.90%
发文量
65
审稿时长
12 weeks
期刊介绍: Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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