Fabrication and evaluation magnetic nanoparticles loaded with cefixime

Kanza Amjad, Ume Habiba, Talib Hussain, Safiullah Khan, Muhammad Akram Choohan
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引用次数: 2

Abstract

Background. Bacterial infections are an important cause of serious health issues worldwide. Various antibacterial drugs have been developed but they have numerous side effects. Development of drug loaded magnetic nanoparticles will help to achieve targeted drug delivery while sustaining the release of drug. It will also enhance its antibacterial activity by using iron oxide. Method. Drug loaded iron oxide nanoparticles were developed to sustain and enhance the antibacterial activity of drug. Chitosan was used as a polymer. The method adopted to prepare magnetic nanoparticles was co-precipitation. Formulated magnetic nanoparticles were tested for drug release, surface morphology, antibacterial activity and FTIR. Results. It was observed from the findings that both formulations were effectively loaded with drugs. The SEM results showed the semi spherical nanoparticles effectively loaded with drug. FTIR spectrum revealed characteristic peaks related to functional groups. Raman spectroscopy showed characteristic bands of both drugs and drug loaded iron oxide nanoparticles. Antibacterial assay results showed an enhanced antibacterial activity by using iron oxide nanoparticles. Conclusion. It was concluded from the study that magnetic nanoparticles could be one of the best approaches to load antibacterial drugs while sustaining and enhancing their antibacterial activity
头孢克肟磁性纳米颗粒的制备与评价
背景。细菌感染是全球严重健康问题的一个重要原因。各种抗菌药物已经开发出来,但它们有许多副作用。磁性载药纳米颗粒的开发将有助于在维持药物释放的同时实现靶向给药。使用氧化铁还可以增强其抗菌活性。方法。为了维持和增强药物的抗菌活性,研制了载药氧化铁纳米颗粒。壳聚糖是一种聚合物。采用共沉淀法制备磁性纳米颗粒。对制备的磁性纳米颗粒进行了药物释放、表面形貌、抗菌活性和红外光谱测试。结果。从调查结果可以看出,这两种配方都有效地装载了药物。扫描电镜结果表明,半球形纳米颗粒有效地负载了药物。FTIR光谱显示与官能团相关的特征峰。拉曼光谱显示了药物和载药氧化铁纳米颗粒的特征谱带。抗菌实验结果表明,氧化铁纳米颗粒具有较强的抗菌活性。结论。研究结果表明,磁性纳米颗粒是一种负载抗菌药物并保持和增强其抗菌活性的最佳途径之一
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