Farah Ballout, H. Gali-Muhtasib
{"title":"Thymoquinone: A Potential Therapy against Cancer Stem Cells","authors":"Farah Ballout, H. Gali-Muhtasib","doi":"10.5530/PHREV.2020.14.19","DOIUrl":null,"url":null,"abstract":"Copyright © 2020 Phcog.Net. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 International license. ABSTRACT Background: Cancer remains to be a major health problem despite advances in treatment. Chemoand radiotherapy resistance accounting for cancer recurrence have been recently attributed to a subpopulation of cells within the tumor, namely cancer stem cells (CSCs). Aim: Hence, it is essential to adopt new therapeutic approaches that target these cells. Methods and Results: The black seed extract Thymoquinone (TQ) has shown promising anti-cancer effects on various cancer types. Here, we provide an overview of TQ’s potential in targeting CSCs with emphasis on its mechanism of action and shed light on its development as a future drug for cancer therapy. Conclusion: TQ showed potency against CSCs either alone or in combination with chemotherapeutic agents.","PeriodicalId":74432,"journal":{"name":"Pharmacognosy reviews","volume":"70 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacognosy reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/PHREV.2020.14.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
百里醌:抗癌干细胞的潜在疗法
版权所有©2020 Phcog.Net这是一篇基于知识共享署名4.0国际许可协议的开放获取文章。背景:尽管在治疗方面取得了进展,但癌症仍然是一个主要的健康问题。癌症复发的化疗和放疗耐药性最近被归因于肿瘤内的一个细胞亚群,即癌症干细胞(CSCs)。目的:因此,采用针对这些细胞的新治疗方法至关重要。方法与结果:黑籽提取物百里醌(TQ)对多种癌症均有良好的抗癌作用。在这里,我们概述了TQ靶向CSCs的潜力,重点介绍了其作用机制,并阐明了其作为未来癌症治疗药物的发展。结论:TQ单用或联用化疗药物对CSCs均有一定的抑制作用。
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