Environmental Chemicals Altered in Association With Deployment for High Risk Areas.

Q1 Medicine

International Journal of Occupational and Environmental Medicine Pub Date : 2019-12-01 DOI:10.1097/JOM.0000000000001647

Matthew Ryan Smith, Karan Uppal, Douglas I Walker, Mark J Utell, Philip K Hopke, Timothy M Mallon, Pamela L Krahl, Patricia Rohrbeck, Young-Mi Go, Dean P Jones

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Abstract

Objective: A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).

Methods: Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.

Results: Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.

Conclusion: These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.

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与高风险地区部署相关的环境化学物质改变。

目的：利用血清样本和高分辨率代谢组学（HRM）进行了一项研究，以测试在高风险地区部署的环境化学物质丰度的变化(伊拉克巴拉德；阿富汗巴格拉姆)。方法：采用人力资源管理和生物信息学的方法，对部署前和部署后的血清样本进行分析，分析271种环境化学物质的相对丰度。结果：271种化学物质中，至少80%的样品中有153种是可测量的。在控制区以及巴格拉姆和巴拉德的样本中，几种杀虫剂和其他化学品在部署后略有增加。同样，一些化学物质的含量也出现了小幅下降。结论：血清检测结果表明，271种环境化学物质检出率为56%，分布在高危地区差异不大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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