A study of the anti-ulcer activity of the ethanolic extract of the leaves of Psidium guajava on experimental animal models

Abstract

The aim of the study is to study the anti-ulcer activity of the ethanolic extract of theleaves of Psidium guajava on experimental animal models. Four groups of albino rats weighing 130-180grams were taken for the study (n=6).Group I : control (3%gum acacia 5ml/kg/day orally for 7days).Group II :Experimental control(Aspirin 400mg/kg orally as single dose on 7th day).Group III :Test (Psidium guajava extract 200mg/kg/day orally for 7days and Aspirin 400mg/kg orally on 7th day) and Group IV:Standard(Ranitidine150mg/kg orally for 7days and Aspirin 400mg/kg orally on 7th day).The stomachs of the sacrificed rats were removed and (1)volume of gastric juice (2)ulcer index (3)pepsin activity(4)free acidity(5)total acidity (6)gastric mucus secretion were studied. The ulcer index, pepsin activity, free and total acidity and volume of gastric juice in group III and IV showed significant decrease in comparison to group II whereas there is increase in gastric mucus secretion (p<.01).