Influence of narrow‐band ultraviolet B therapy on sirtuin 1 expression in lesional skin of patients with chronic plaque psoriasis: Relation to clinical improvement and interferon‐γ expression

Abstract

Reduced sirtuin 1 (Sirt1) expression in psoriasis was previously reported, and its activation was associated with disease improvement. Narrow‐band ultraviolet B (NB‐UVB) downregulates several pro‐inflammatory cytokines such as interferon‐γ (IFN‐γ) and influences keratinocyte differentiation in psoriasis.