Application of Carbon Nanotubes for Controlled Release of Growth Factors or Endocannabinoids: A Breakthrough in Biomedicine

P. Hassanzadeh, F. Atyabi, R. Dinarvand
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引用次数: 15

Abstract

Carbon nanotubes, the nanostructures with immense potential in various scientific fields such as the regenerative medicine, have emerged as innovative nanosreservoirs with multimodal functionality and application in theranostic sessions. The superior mechanical properties, high thermoelectrical conductivities, or improved solubility and biocompatibility have made CNTs as suitable candidates for biosensing, high-resolution imaging, tissue-engineering, and delivery of a variety of compounds with poor solubility or short half-life. These advanced nanovectors which promote neuronal growth and functional connectivity, have shown great theranostic potential in the central nervous system disorders. Several pioneering works have shown the ability of CNTs for controlled release of drugs or growth factors into the brain. Over the last decade the neurotropic and metabotrophic effects of nerve-growth factor, brain-derived neurothropic factor and endocannabinoid system and their involvement in the mechanism of action of a wide variety of drugs have been the focus of intense research. In order to overcome the rapid degradation and/or non-specific distribution of nerve-growth factor or endocanabinoids, conjugation with CNTs has led to the prolonged effects of these modulating factors. Based on their unique properties, the appropriate application of functionalized CNTs may indeed revolutionize the current biomedical interventions that has been highlighted in the present review.
碳纳米管在生长因子或内源性大麻素控释中的应用:生物医学的一个突破
碳纳米管作为一种具有多模态功能的新型纳米储存库,在再生医学等多个科学领域具有巨大的应用潜力。优异的机械性能、高热电导电性或改善的溶解度和生物相容性使CNTs成为生物传感、高分辨率成像、组织工程和递送各种溶解度差或半衰期短的化合物的合适候选者。这些先进的纳米载体促进神经元生长和功能连接,在中枢神经系统疾病中显示出巨大的治疗潜力。一些开创性的工作已经表明,碳纳米管能够控制药物或生长因子释放到大脑中。近十年来,神经生长因子、脑源性神经促性因子和内源性大麻素系统的神经促代谢作用及其在多种药物作用机制中的作用已成为研究的热点。为了克服神经生长因子或内源性大麻素的快速降解和/或非特异性分布,与碳纳米管的结合导致这些调节因子的作用延长。基于其独特的性质,适当应用功能化碳纳米管确实可能彻底改变当前的生物医学干预措施,这在本综述中得到了强调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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