Alcohol and inflammation: Examining differences at the intersection of sexual identity and race/ethnicity

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2023-11-11 DOI:10.1016/j.alcohol.2023.11.002

Ethan Morgan , Allen Mallory , Nathaniel Albright , Christina Dyar

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引用次数: 0

Abstract

Sexual minorities (SMs; e.g., lesbian, gay, bisexual, and other non-heterosexual individuals) are more likely to be current alcohol drinkers than their heterosexual peers while separately experiencing elevated inflammation. Yet, little research has assessed the association between alcohol use and inflammation among subgroups of SMs, let alone potential differences among people with multiple marginal identities (e.g., race/ethnicity and sexual identity).

Data came from the National Health and Nutrition Survey 2015–2016. Survey-weighted multivariable linear regression analysis was used to assess the relationship between alcohol use categories, heavy episodic drinking, and log-CRP (C-reactive protein). Models were stratified by sexual identity to determine whether associations between alcohol use and inflammation or between race/ethnicity and inflammation differed by sexual identity.

Among 3220 participants, 1000 (36.8%) reported light alcohol use, 870 (32.0%) reported moderate use, and 483 (17.8%) reported heavy use. Mean raw CRP was 4.1 mg/L (SD = 8.1). The association between race/ethnicity and CRP differed in stratified relative to non-stratified models with key differences in CRP among individuals with multiple marginalized identities. We also observed that while the “classic” J-shaped relationship between alcohol use and systemic inflammation persists among heterosexuals in this sample, it does not hold among subgroups of sexual minorities. In particular, bisexuals who report heavy alcohol use, compared to non-users, experience significantly elevated CRP. Finally, we did not observe any association between heavy episodic drinking and CRP among subgroups of sexual minorities.

Future studies assessing alcohol and biomarker data need to strive to include subgroups of sexual minorities and people with multiple marginal identities to better target behavioral and biomedical interventions aimed at reducing health disparities.

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酒精和炎症:检查性别认同和种族/民族交叉的差异。

性少数群体(SMs;例如，女同性恋、男同性恋、双性恋和其他非异性恋个体)比异性恋同伴更有可能是目前的饮酒者，同时单独经历炎症升高。然而，很少有研究评估SMs亚组中酒精使用与炎症之间的关系，更不用说具有多种边缘身份(例如种族/民族和性别身份)的人群之间的潜在差异。数据来自2015-2016年全国健康与营养调查。使用调查加权多变量线性回归分析来评估酒精使用类别、重度间歇性饮酒和log CRP之间的关系。模型按性别身份分层，以确定酒精使用与炎症之间或种族/民族与炎症之间的关联是否因性别身份而异。在3220名参与者中，1000人(36.8%)报告轻度饮酒，870人(32.0%)中度饮酒，483人(17.8%)重度饮酒。平均原CRP为4.1 mg/L (SD = 8.1)。种族/民族与CRP之间的关联在分层模型与非分层模型中存在差异，具有多个边缘身份的个体之间的CRP存在关键差异。我们还观察到，虽然该样本中异性恋者饮酒与全身炎症之间的“经典”j型关系仍然存在，但在性少数亚群中却不成立。特别是，与不饮酒的双性恋者相比，重度饮酒的双性恋者的CRP水平明显升高。最后，我们没有观察到在性少数亚群中大量间歇性饮酒和CRP之间的任何关联。未来评估酒精和生物标志物数据的研究需要努力包括性少数亚群体和具有多种边缘身份的人，以更好地针对旨在减少健康差距的行为和生物医学干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.