Predictive Value of GDF-15 and sST2 for Pulmonary Hypertension in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

IF 2.7 3区医学 Q2 RESPIRATORY SYSTEM

International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-11-06 eCollection Date: 2023-01-01 DOI:10.2147/COPD.S429334

Zhigan Lv, Guohua Liang, Mengyu Cheng

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引用次数: 0

Abstract

Objective: To confirm whether growth differentiation factor-15 (GDF-15) and soluble suppression of tumorigenicity 2 (sST2) are indicators of pulmonary hypertension in acute exacerbation of chronic obstructive pulmonary disease (AECOPD-PH).

Methods: All patients admitted to the hospital with AECOPD between July 2020 and October 2021 were enrolled. The patients were then categorized into AECOPD and AECOPD-PH groups according to PH probability, and the differences in GDF-15 and sST2 serum levels in the AECOPD and AECOPD-PH groups were compared. Correlation analysis was carried out to explore the association between GDF-15 and sST2 serum levels and the length of hospital stay of patients with AECOPD-PH. Receiver operating characteristic curve analysis was used to assess the clinical significance of GDF-15 and sST2 in predicting patients with AECOPD-PH.

Results: Included in this study were 126 patients with AECOPD, including 69 with AECOPD and 57 with AECOPD-PH. The serum levels of GDF-15 and sST2 in the AECOPD-PH group were significantly higher than those in the AECOPD group (P < 0.05). There was no significant correlation between the length of hospital stay in AECOPD-PH patients and GDF-15 and sST2 serum levels (P > 0.05). The area under the curves of GDF-15, sST2, and GDF-15 + sST2 for predicting AECOPD-PH and AECOPD-PH patients with poor prognosis were >0.60 and 0.70, respectively. The optimal cutoff values of GDF-15 and sST2 for predicting AECOPD-PH were 1125.33 pg/mL and 80.68 ng/mL and 1309.72 pg/mL and 59.10 ng/mL for predicting AECOPD-PH patients with poor prognosis, respectively.

Conclusion: GDF-15 and sST2 levels may be useful in the prediction of AECOPD-PH.

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GDF-15和sST2对慢性阻塞性肺疾病急性加重期肺动脉高压的预测价值

目的:探讨生长分化因子-15 (GDF-15)和可溶性致瘤性抑制2 (sST2)是否为慢性阻塞性肺疾病急性加重期(AECOPD-PH)肺动脉高压的指标。方法:纳入2020年7月至2021年10月期间入院的所有AECOPD患者。根据PH概率将患者分为AECOPD组和AECOPD-PH组，比较AECOPD组和AECOPD-PH组血清GDF-15和sST2水平的差异。通过相关分析探讨血清GDF-15和sST2水平与AECOPD-PH患者住院时间的关系。采用受试者工作特征曲线分析，评价GDF-15和sST2在预测AECOPD-PH患者中的临床意义。结果:本研究纳入126例AECOPD患者，其中AECOPD 69例，AECOPD- ph 57例。AECOPD- ph组血清GDF-15、sST2水平显著高于AECOPD组(P < 0.05)。AECOPD-PH患者住院时间与血清GDF-15、sST2水平无显著相关性(P < 0.05)。GDF-15、sST2和GDF-15 + sST2预测AECOPD-PH和预后不良患者AECOPD-PH的曲线下面积分别为0.60和0.70。预测AECOPD-PH的最佳临界值GDF-15和sST2分别为1125.33 pg/mL和80.68 ng/mL，预测预后较差的AECOPD-PH患者的最佳临界值分别为1309.72 pg/mL和59.10 ng/mL。结论:GDF-15和sST2水平可用于预测AECOPD-PH。

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来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

4.80

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals