Sugar-Rich Food Intake Is Negatively Associated with Plasma Pentraxin 3 Levels.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Obesity & Metabolic Syndrome Pub Date : 2023-12-30 Epub Date: 2023-11-13 DOI:10.7570/jomes23027

Asako Zempo-Miyaki, Hiroshi Kumagai, Koichiro Tanahashi, Hirofumi Zempo, Takeshi Otsuki, Seiji Maeda

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引用次数: 0

Abstract

Background: Levels of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, increase after weight loss in obese men and aerobic exercise in non-obese adults. However, the effect of nutritional characteristics on PTX3 levels remains unclear. This population-based, cross-sectional study investigated the association between circulating PTX3 levels and food intake in Japanese adults.

Methods: We hypothesized that the consumption of high amounts of high-sugar foods would lead to low plasma PTX3 levels, resulting in obesity. This study included 327 participants categorized depending on the consumption of the recommended amount of confectionary and sugar-sweetened beverages (CSSB) into high and low groups.

Results: PTX3 levels were significantly lower in the high CSSB group than in the low CSSB group. Biological sex was the strongest effector of PTX3 levels. Moreover, the intake of Tsukudani and CSSB, as well as some metabolic syndrome factors, also affect PTX3 levels. In the groups categorized by sex and age, the determinants of PTX3 levels differed. Body mass index, waist circumference (WC), and high-density lipoprotein cholesterol (HDL-C) were significantly associated with PTX3 levels in women. Tsukudani, HDL-C, heart rate, saturated fatty acids, systolic blood pressure, and CSSB were associated with PTX3 levels in individuals aged >65 years.

Conclusion: Our results show that circulating PTX3 levels are affected by sex, sugar-rich foods, and metabolic syndrome characteristics (WC, HDL-C).

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高糖食物摄入与血浆戊烷素3水平呈负相关。

背景:肥胖男性体重减轻和非肥胖成年人进行有氧运动后，戊烷素3 (PTX3)水平升高，这是一种抗炎的心脏保护蛋白。然而，营养特性对PTX3水平的影响尚不清楚。这项以人群为基础的横断面研究调查了日本成年人循环PTX3水平与食物摄入量之间的关系。方法:我们假设摄入大量高糖食物会导致血浆PTX3水平降低，从而导致肥胖。这项研究包括327名参与者，根据糖果和含糖饮料(CSSB)的推荐摄入量分为高组和低组。结果:高CSSB组PTX3水平明显低于低CSSB组。生理性别对PTX3水平的影响最大。此外，筑草谷和CSSB的摄入以及一些代谢综合征因素也会影响PTX3水平。在按性别和年龄分类的人群中，PTX3水平的决定因素有所不同。女性的体重指数、腰围(WC)和高密度脂蛋白胆固醇(HDL-C)与PTX3水平显著相关。在50 ~ 65岁的人群中，Tsukudani、HDL-C、心率、饱和脂肪酸、收缩压和CSSB与PTX3水平相关。结论:我们的研究结果表明，循环PTX3水平受性别、富含糖的食物和代谢综合征特征(WC、HDL-C)的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

8.30

自引率

9.60%

发文量

审稿时长

19 weeks

期刊介绍： The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).