Transcriptomic signature of bacteria exposed to benzalkonium chloride

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Research in microbiology Pub Date : 2024-05-01 DOI:10.1016/j.resmic.2023.104151

Samantha J. McCarlie , Louis L. du Preez , Julio Castillo Hernandez , Charlotte E. Boucher , Robert R. Bragg

引用次数: 0

Abstract

The COVID-19 pandemic has highlighted our reliance on biocides, the increasing prevalence of resistance to biocides is a risk to public health. Bacterial exposure to the biocide, benzalkonium chloride (BAC), resulted in a unique transcriptomic profile, characterised by both a short and long-term response. Differential gene expression was observed in four main areas: motility, membrane composition, proteostasis, and the stress response. A metabolism shift to protect the proteome and the stress response were prioritised suggesting these are main resistance mechanisms. Whereas “well-established” mechanisms, such as biofilm formation, were not found to be differentially expressed after exposure to BAC.

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暴露于苯扎氯铵的细菌转录组学特征。

2019冠状病毒病大流行凸显了我们对杀菌剂的依赖，对杀菌剂的耐药性日益普遍对公共卫生构成风险。细菌暴露于杀菌剂苯扎氯铵(BAC)会导致独特的转录组谱，其特征是短期和长期反应。在四个主要领域观察到差异基因表达:运动性、膜组成、蛋白酶抑制和应激反应。保护蛋白质组的代谢转变和应激反应被优先考虑，这表明这些是主要的耐药机制。然而，“成熟的”机制，如生物膜的形成，在暴露于BAC后没有发现差异表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in microbiology 生物-微生物学

CiteScore

4.10

自引率

3.80%

发文量

审稿时长

16 days

期刊介绍： Research in Microbiology is the direct descendant of the original Pasteur periodical entitled Annales de l''Institut Pasteur, created in 1887 by Emile Duclaux under the patronage of Louis Pasteur. The Editorial Committee included Chamberland, Grancher, Nocard, Roux and Straus, and the first issue began with Louis Pasteur''s "Lettre sur la Rage" which clearly defines the spirit of the journal:"You have informed me, my dear Duclaux, that you intend to start a monthly collection of articles entitled "Annales de l''Institut Pasteur". You will be rendering a service that will be appreciated by the ever increasing number of young scientists who are attracted to microbiological studies. In your Annales, our laboratory research will of course occupy a central position, but the work from outside groups that you intend to publish will be a source of competitive stimulation for all of us."That first volume included 53 articles as well as critical reviews and book reviews. From that time on, the Annales appeared regularly every month, without interruption, even during the two world wars. Although the journal has undergone many changes over the past 100 years (in the title, the format, the language) reflecting the evolution in scientific publishing, it has consistently maintained the Pasteur tradition by publishing original reports on all aspects of microbiology.