Carotane sesquiterpenes from Peperomia pellucida and their anti-infective activities

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2023-11-07 DOI:10.1080/14786419.2023.2280923

Quynh-Mai Thi Ngo , Ngan Thi Tran , Phuong Nguyen Thi Thu , Thu Nguyen Thi , Khoa Nguyen Manh , Hung Nguyen Van , Linh Pham Van , Khai Nguyen Van

引用次数: 0

Abstract

Owing to the challenges of antimicrobial resistance, investigations of new antibiotics from medicinal plants are continuously being conducted. Peperomia pellucida is a pantropical plant used in traditional medicine for the treatment of various disorders. From the ethanol extract of a whole P. pellucida plant, one previously undescribed carotane sesquiterpene (pellucarotine), one known carotane sesquiterpene (daucol), and one phenylpropanoid (dillapiol) were isolated and structurally elucidated. Their structures were determined based on 1D and 2D NMR, HR-ESI-Mass, experimental, and computational electronic circular dichroism spectroscopic data and compared with those reported in the literature. Antimicrobial assay results showed that pellucarotine had an anti-infective effect on Candida albicans with an MIC of 512 µg/mL.

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透明胡椒中胡萝卜烷倍半萜及其抗感染活性。

由于抗菌素耐药性的挑战，从药用植物中提取新的抗生素的研究正在不断进行。透明胡椒是一种泛热带植物，在传统医学中用于治疗各种疾病。从一株透明叶青的乙醇提取物中分离出一种先前未被描述的胡萝卜烷倍半萜(pellucar棕)、一种已知的胡萝卜烷倍半萜(daucol)和一种苯丙醇(dillapiol)，并对其进行了结构鉴定。基于一维和二维NMR、HR-ESI-Mass、实验和计算电子圆二色光谱数据确定了它们的结构，并与文献报道的结构进行了比较。抗菌实验结果表明，透明椰油甙对白色念珠菌具有抗感染作用，MIC为512µg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.