Antiproliferative effect of natural and semisynthetic polyethers from Laurencia viridis.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-01 Epub Date: 2023-11-11 DOI:10.1080/14786419.2023.2280176

Adrián J Santiago-Benítez, Adrián Puerta, José M Padrón, Manuel Norte, José J Fernández, Antonio Hernández Daranas, Francisco Cen-Pacheco

引用次数: 0

Abstract

Squalene-derived polyethers are a unique class of compounds that display a great diversity of structures and a broad array of bioactivities, among which its notable antiproliferative activity stands out against various types of cancer cell lines. In this study, eighteen triterpene squalene-derived polyethers, including twelve natural products and six synthetic derivatives, obtained from the red alga Laurencia viridis Gil-Rodríguez & Haroun were screened for their antiproliferative activity against six cancer cell lines: A549, HBL-100, HeLa, SW1573, T-47D, and WiDr; and a structure-activity relationship (SAR) study was established.

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天然聚醚和半合成聚醚的抗增殖作用。

角鲨烯衍生聚醚是一类独特的化合物，具有多种结构和广泛的生物活性，其中对多种类型的癌细胞具有显著的抗增殖活性。从红藻www.laurencia viridis Gil-Rodríguez和Haroun中提取了18种三萜角鲨烯衍生聚醚，其中包括12种天然产物和6种合成衍生物，对A549、HBL-100、HeLa、SW1573、T-47D和WiDr 6种癌细胞进行了抗增殖活性筛选;并建立构效关系(SAR)研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.