Lower Vitamin D Levels are Associated with Higher Seroprevalence of Toxoplasma gondii—a US National Survey Study

Jiaofeng Huang, Yinlian Wu, Mingfang Wang, Yueyong Zhu, Su Lin
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引用次数: 2

Abstract

Vitamin D deficiency is associated with high susceptibility to infections. The present study aimed at exploring the relationship between vitamin D levels and Toxoplasma gondii (T. gondii) infection, on the basis of a nationally representative database. The study data came from the National Health and Nutrition Examination Surveys (NHANES) 2001–2004. Participants underwent both Toxoplasma IgG antibody testing and serum vitamin D testing. Vitamin D deficiency was defined by a serum 25-hydroxyvitamin D level <20 ng/mL. Multivariate logistic regression and propensity score matching were used to adjust for potential confounders. All analyses were conducted in R software. A total of 10613 participants were included. Among these, 3973 (37.4%) were vitamin D deficient, and 2070 (19.5%) were seropositive for T. gondii IgG antibody. Vitamin D deficiency was found in 42.3% of the seropositive population, compared with 36.3% of the seronegative population (P<0.001). After adjustment for sex, age, body mass index, smoking history, drinking history and testing season, vitamin D deficiency was associated with an elevated risk of T. gondii infection (OR=1.303, 95% CI=1.136–1.495, P<0.001). This effect persisted in the propensity matching cohort. Low vitamin D levels are associated with high seroprevalence of T. gondii.
较低的维生素D水平与较高的弓形虫血清患病率相关——一项美国国家调查研究
维生素D缺乏与感染的高易感性有关。本研究旨在探讨维生素D水平与弓形虫(弓形虫)感染之间的关系,在全国代表性的数据库的基础上。研究数据来自2001-2004年国家健康和营养检查调查(NHANES)。参与者进行了弓形虫IgG抗体检测和血清维生素D检测。血清25-羟基维生素D水平<20 ng/mL为维生素D缺乏。使用多元逻辑回归和倾向评分匹配来调整潜在的混杂因素。所有分析均在R软件中进行。调查共包括10613名参与者。其中维生素D缺乏3973人(37.4%),弓形虫IgG抗体阳性2070人(19.5%)。血清阳性人群中有42.3%的人缺乏维生素D,血清阴性人群中有36.3%的人缺乏维生素D (P<0.001)。在调整性别、年龄、体重指数、吸烟史、饮酒史和检测季节后,维生素D缺乏与弓形虫感染风险升高相关(OR=1.303, 95% CI=1.136 ~ 1.495, P<0.001)。这种效应在倾向匹配队列中持续存在。低维生素D水平与高弓形虫血清患病率有关。
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