A New Heating Control Method for Effective Hyperthermia Treatment of a Brain Tumor Using the Resonant Cavity Applicator with a Segmented Dielectric Bolus

Y. Iseki, Hideaki Takahashi, T. Uzuka, Kazuo Kato
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引用次数: 2

Abstract

This paper describes a new heating control method of the proposed resonant cavity applicator for non-invasive brain tumor hyperthermia treatments. In the previous study, the resonant cavity applicator for treating brain tumors was proposed. In the present study,a dielectric bolus was used to control the heated location inside brain tumors. The dielectric bolus was divided into four sections filled with dielectric materials,such as water,and was attached to the human head inside the cavity. By changing the dielectric materials inside each section,the heated location could be controlled inside brain tumors. In this paper,first,the method for controlling the heated location with the dielectric bolus was presented. Second,two types of numerical models to calculate temperature distributions were described. First,we used a cylindrical phantom model for the basic study to check the ability of the proposed method. Second,we used a 3-D anatomical human head model which was reconstructed from 2-D medical images by using the 3-D computer aided design (CAD) software. Finally, the temperature profiles calculated by the 3-D finite element method (FEM) and heating experiments heated by the developed heating system were discussed. From the results of computer simulations and heating experiment with the agar phantom,it was confirmed that the results of the computer simulations were in close agreement with the results of the heating experiments with an error of 10% or less. Next,we calculated the temperature distribution of the 3-D anatomical human head model that takes into account the cooling effect of blood flow. The proposed heating method covered approximately 97% of the brain tumor size without an undesirable hotspot. From these results,it was found that the proposed heating control method is useful for effective hyperthermia treatments.
分段电介质丸谐振腔加药器对脑肿瘤有效热疗的加热控制新方法
本文介绍了一种用于脑肿瘤非侵入性热疗的谐振腔应用器的加热控制方法。在以往的研究中,提出了一种用于脑肿瘤治疗的谐振腔应用器。在本研究中,使用电介质丸来控制脑肿瘤内的加热位置。电介质丸被分成四个部分,其中充满了电介质材料,例如水,并被附着在腔内的人的头部上。通过改变每个部分内部的介电材料,可以控制脑肿瘤内部的加热位置。本文首先提出了用介质丸控制加热位置的方法。其次,介绍了两种计算温度分布的数值模式。首先,我们使用圆柱体模型进行基础研究,以检验所提出方法的能力。其次,利用三维计算机辅助设计(CAD)软件从二维医学图像重建三维人体头部解剖模型。最后,讨论了三维有限元法计算的温度分布和所开发的加热系统的加热实验。计算机模拟和琼脂模体加热实验结果表明,计算机模拟结果与加热实验结果吻合较好,误差不超过10%。接下来,我们计算了考虑血流冷却效应的三维人体头部解剖模型的温度分布。所提出的加热方法覆盖了大约97%的脑肿瘤大小,没有不良热点。从这些结果中发现,所提出的加热控制方法可用于有效的热疗治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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