Time-sensitive effects of Zhuang Medicated Thread Moxibustion on Estrogen Level in female perimenopausal Model Rats.

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2021-04-09 DOI:10.22541/AU.161796662.26625743/V1

Dan Liang, Yun Zhang, Z. Cao, Jingqin Chen, Zhuli Hou, L. Mao, Yuhan Pan, Ke Lu, Gang Fang

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Abstract

Abstract Background: To ascertain the estrogenic effect of Zhuang Medicated Thread Moxibustion (ZMTM) and explore its time-sensitive impact on estradiol in female perimenopausal rats. Methods: Female rats were randomized into four groups of 10 rats, each consisting of the control, model, ZMTM, and acupuncture groups. The perimenopausal syndrome was induced in the last three groups with a daily subcutaneous dose of 80 mg/kg of 4- vinylcyclohexene diepoxide for 15 days. Afterward, rats in the model and control groups were fed routinely, while rats in the ZMTM and acupuncture groups were treated with six ZMTM and acupuncture courses, respectively. The rats’ general condition and estradiol (E2) levels in the rats’ serum were assessed. Results: Following the six courses of treatment, the E2 level in the model group was significantly the lowest, while the regular group was the highest (P < 0.05). There was also a gradual increase in the E2 level of the ZMTM group compared to the model and acupuncture groups, such that after the 5th and 6th courses of treatment, their E2 level was significantly higher than the model and acupuncture groups (P < 0.05). The control group had a better condition than all other groups, while the ZMTM group was better than the model and acupuncture groups. Conclusion: ZMTM can improve perimenopausal induced rats’ estrogen level, and this effect becomes better with each further treatment course.

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壮药线灸对女性围绝经期模型大鼠雌激素水平的时敏性影响。

摘要背景:探讨壮药线灸对围绝经期雌性大鼠雌激素的影响，并探讨其对雌二醇的时间敏感性。方法:将雌性大鼠随机分为4组，每组10只，每组分为对照组、模型组、中药组和针刺组。后3组小鼠每日皮下注射4-乙烯基二氧化环己烯80 mg/kg，连续15 d诱导围绝经期综合征。随后，模型组和对照组大鼠进行常规喂养，中药汤剂组和针刺组大鼠分别进行6个疗程的中药汤剂和针刺治疗。测定大鼠一般情况及血清雌二醇(E2)水平。结果:治疗6个疗程后，模型组E2水平明显最低，常规组最高(P< 0.05)。ZMTM组E2水平也较模型组和针刺组逐渐升高，治疗第5、6个疗程后E2水平显著高于模型组和针刺组(P< 0.05)。对照组较其他各组好，中药组较模型组和针刺组好。结论:ZMTM能提高围绝经期妇女的雌激素水平，且随着疗程的延长，效果越来越好。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.