Bacopa monnieri: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-01 DOI:10.37360/blacpma.22.21.2.09

Andreia F. M. Santos, Marília Moraes Queiroz Souza, K. Pauli, Gustavo Ratti da Silva, Midia Wolff Marques, P. A. Auth, W. Bortolucci, Z. C. Gazim, G. Linde, N. Colauto, E. C. W. Lovato, F. Lívero

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引用次数: 0

Abstract

Bacopa monnieri(L.) Wettst. (Plantaginaceae), also known as Brahmi, has been used to improve cognitive processes and intellectual functions that are related to the preservation of memory. The objective of this research is to review the ethnobotanical applications, phytochemical composition, toxicity and activity of B. monnieriin the central nervous system. It reviewed articles on B. monnieriusing Google Scholar, SciELO, Science Direct, Lilacs, Medline, and PubMed. Saponins are the main compounds in extracts of B. monnieri. Pharmacological studies showed that B. monnieriimproves learning and memory and presents biological effects against Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. No preclinical acute toxicity was reported. However, gastrointestinal side effects were reported in some healthy elderly individuals. Most studies with B. monnierihave been preclinical evaluations of cellular mechanisms in the central nervous system and further translational clinical research needs to be performed to evaluate the safety and efficacy of the plant.

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假马齿苋:治疗中枢神经系统疾病药理作用的历史研究

一种monnieri (l)Wettst。(车前草科)，也被称为婆罗门，已被用于改善与保存记忆有关的认知过程和智力功能。本文综述了monnieriin在民族植物学中的应用、植物化学成分、毒性和中枢神经系统的活性。它使用Google Scholar, SciELO, Science Direct, Lilacs, Medline和PubMed对B. monnierii的文章进行了审查。皂苷是蒙氏菌提取物的主要成分。药理学研究表明，念珠菌可以改善学习和记忆，并对阿尔茨海默病、帕金森病、癫痫和精神分裂症有生物效应。无临床前急性毒性报告。然而，在一些健康的老年人中报告了胃肠道副作用。大多数关于monnierib的研究都是对中枢神经系统细胞机制的临床前评估，需要进一步的临床转化研究来评估该植物的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.