Relationships between psoriasis severity indices and dermatological life quality index in children with psoriasis

Е.О. Murzina, Yu.А. Rokhletsova
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Abstract

Objective — to аssess the impact of dermatosis on the quality of life of children with psoriasis. Materials and methods. Psoriasis severity indices (BSA, PASI, PGA) and dermatological life quality indices (DLQI, CDLQI) in children with psoriasis aged 4 to 17 years depending on the clinical and epidemiological features of dermatosis were determined. A correlation analysis of the presence of a relationship between the obtained indicators was carried out. Results and discussion. In 73.81 % of children, the BSA index was higher than 10, which provided an average BSA of 25.85 (8.78—38.38). The calculated PASI index at the beginning of treatment averaged 9.3 (3.6—18.9). 53.06 % of children had PASI < 10. The PASI index at the first diagnosis was almost 1.5 times lower than in relapses (p = 0.043). The average PGA index was 3 (2—3), namely, 32.99 % of children had PGA 1—2, 43.20 % had PGA 3 and 23.81 % of children had PGA 4. In the group of children aged 4—7 years, there was the smallest number of participants with the PGA index 4 (7.69 %), while in the group aged 16/17—17 years, this number was the largest (41.49 %) (p = 0.039). The calculated DLQI in children with psoriasis was 5 [3—9]. The average DLQI indicator in the group of girls was statistically higher than in the group of boys (p = 0.016). Statistically significant differences were identified between DLQI in the age groups, where the highest impact on quality of life was found for the children aged 16—17 years (p < 0.001) and depended on the clinical form of psoriasis: in scalp psoriasis, the impact on quality of life was moderate, and in inverse psoriasis, it was insignificant (p = 0.021). It was found that in moderate­severe/severe psoriasis, the impact on the quality of life in children increased and was assessed as moderate, while in mild psoriasis, the impact was assessed as minor (p < 0.05). Conclusions. The course of psoriasis in children can be assessed as moderate and severe, but in the first episodes of psoriasis in droplet and inverse forms, the course is mostly mild. The intensity of skin manifestations increases with age, especially in case of the disease recurrences in the plaque form. On the whole in children, psoriasis has an ambiguous impact on the quality of life: in boys, the impact of the disease is minor; in girls, it is moderate. Damage to the visible skin areas caused by psoriasis, an increase in the area affected by the pathological process and an increase in the intensity of skin manifestations with age leads to a more negative impact on the quality of life of a child.
银屑病患儿严重程度指数与皮肤生活质量指数的关系
目的:评估皮肤病对牛皮癣患儿生活质量的影响。材料和方法。根据皮肤病的临床和流行病学特征,测定4 ~ 17岁银屑病患儿的银屑病严重程度指数(BSA、PASI、PGA)和皮肤生活质量指数(DLQI、CDLQI)。对所获得的指标之间存在的关系进行了相关分析。结果和讨论。73.81%的儿童BSA指数大于10,平均BSA为25.85(8.78 ~ 38.38)。治疗开始时计算的PASI指数平均为9.3(3.6 ~ 18.9)。53.06%患儿PASI < 10。首次诊断时PASI指数比复发时低近1.5倍(p = 0.043)。平均PGA指数为3(2-3),即PGA 1-2患儿占32.99%,PGA 3患儿占43.20%,PGA 4患儿占23.81%。4 ~ 7岁儿童中PGA指数为4的人数最少(7.69%),16/17 ~ 17岁儿童中PGA指数为4的人数最多(41.49%)(p = 0.039)。银屑病患儿DLQI计算值为5[3-9]。女生组平均DLQI指标高于男生组,差异有统计学意义(p = 0.016)。DLQI在不同年龄组间的差异有统计学意义,其中16-17岁的儿童对生活质量的影响最大(p < 0.001),并取决于牛皮癣的临床形式:头皮牛皮癣对生活质量的影响中等,而逆型牛皮癣对生活质量的影响不显著(p = 0.021)。结果发现,中重度/重度牛皮癣对患儿生活质量的影响增加,评价为中度,轻度牛皮癣对患儿生活质量的影响评价为轻微(p < 0.05)。结论。儿童牛皮癣的病程可分为中度和重度,但在牛皮癣滴状和逆状的首发发作中,病程多为轻度。皮肤表现的强度随着年龄的增长而增加,特别是在斑块形式的疾病复发的情况下。总的来说,在儿童中,牛皮癣对生活质量有模糊的影响:在男孩中,疾病的影响较小;在女孩中,它是适度的。银屑病引起的可见皮肤区域的损伤,受病理过程影响的区域的增加以及皮肤表现强度随着年龄的增长而增加,导致对儿童生活质量的更负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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