Review: Gallotannins; Biosynthesis, Structure Activity Relationship, Anti-inflammatory and Antibacterial Activity

Current cellular biochemistry Pub Date : 2021-06-30 DOI:10.29244/cb.8.1.1

I. Kurniawan, Hafizh Zahra

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引用次数: 1

Abstract

Tannins are one of the main compounds in plants with potential health benefits. Gallotannin is one of the biologically active tannins groups produced by some medicinal plants. Gallotannins is a hydrolyzable tannin compound biosynthesized through gallic acid, shikimic acid, and pentagalloylglucose pathways. Gallotannins can be separated by cascade solvent extraction procedures, column chromatography, and preparative HPLC. This review focuses on the discussion of biosynthesis and structure-activity relationship of tannins as antibacterial and anti-inflammatory. The structure-activity relationship (SAR) and biological activity of gallotannins is caused by the molecular bonds between gallotannins and certain other compounds, especially proteins, which make complex compounds, change physiological and morphological processes in bacterial cells or tissues. The biological activities of gallotannin include anti-inflammatory, anticancer or antitumour, antiviral, antioxidant, antibacterial, and antidiabetic. This review used the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) method approach in a short, concise, and clear summary about tannins through various references. Keywords: Biological activities, Biosynthesis, Gallotannins

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点评:鞣花鞣质;生物合成，构效关系，抗炎和抗菌活性

单宁是植物中具有潜在健康益处的主要化合物之一。没食子丹宁是一些药用植物产生的具有生物活性的单宁基团之一。没食子酸是一种水解单宁化合物，通过没食子酸、莽草酸和五没食子酸葡萄糖途径生物合成。没食子丹宁可以通过级联溶剂萃取、柱层析和制备高效液相色谱法分离。本文就单宁的生物合成及其抑菌抗炎的构效关系作一综述。没食子丹宁的构效关系(SAR)和生物活性是由没食子丹宁与某些其他化合物，特别是蛋白质之间的分子键形成复杂的化合物，改变细菌细胞或组织的生理和形态过程引起的。没食子丹宁的生物活性包括抗炎、抗癌或抗肿瘤、抗病毒、抗氧化、抗菌和抗糖尿病。本综述采用系统评价和荟萃分析首选报告项目(PRISMA)方法，通过各种参考文献对单宁进行了简短、简明、清晰的总结。关键词:生物活性;生物合成;没食子丹宁

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Current cellular biochemistry

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