TSLP activates the production of IFN-γ via CD8-positive T cells in recurrent tonsillitis

Clinical Immunology Communications Pub Date : 2022-12-01 DOI:10.1016/j.clicom.2022.05.002

Kota Hiraoka, Toshiaki Kawano, Takashi Hirano, Masashi Urabe, Kaori Tateyama, Masashi Suzuki

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引用次数: 1

Abstract

The role of thymic stromal lymphopoietin (TSLP) in chronic infection is not well understood. We report an increased number of cluster of differentiation 8 (CD8+ T) cells and higher expression of TSLP in the tonsil tissues of patients with recurrent tonsillitis as compared to that in the tonsil tissues of patients with tonsillar hypertrophy. Stimulation of tonsil CD8+ T cells with TSLP in the recurrent tonsillitis group resulted in higher production of interferon gamma (IFN-γ) and increased cell proliferation when compared to that in the tonsillar hypertrophy group. These results suggest the possibility that recurrent infection of tonsils may enhance local CD8+ T cell proliferation and IFN-γ and TSLP production. Anti-TSLP antibodies, which are potential therapeutic agents in allergic diseases, could have beneficial effects in patients with recurrent tonsillitis.

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TSLP通过cd8阳性T细胞激活复发性扁桃体炎中IFN-γ的产生

胸腺基质淋巴生成素(TSLP)在慢性感染中的作用尚不清楚。我们报道，与扁桃体肥大患者相比，复发性扁桃体炎患者扁桃体组织中CD8+ T细胞簇数量增加，TSLP表达更高。与扁桃体肥大组相比，复发性扁桃体炎组用TSLP刺激扁桃体CD8+ T细胞导致干扰素γ (IFN-γ)的产生增加，细胞增殖增加。这些结果提示扁桃体复发感染可能会增强局部CD8+ T细胞增殖和IFN-γ和TSLP的产生。抗tslp抗体是变应性疾病的潜在治疗药物，可能对复发性扁桃体炎患者有有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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